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---------------

Weight Loss News

Fast Heart Rate Warns of Obesity, Diabetes HealthDay - Thu Dec 11, 11:48 PM ET
THURSDAY, Dec. 11 (HealthDay News) -- A too-fast heartbeat in early adulthood is a warning sign for increased risk of cardiovascular problems decades later on, a Japanese study suggests.

------

Thanks

Cancer to be world's top killer by 2010, WHO says

2008-12-09T09:48:00.001-08:00

From Yahoo news rss feed

AP - 2 hours, 45 minutes ago

Play Video Video: Irish pork recalled amid cancer fears AP

Play Video Video: Teams compete in holiday pudding pandemonium AP

Play Video Video: Expo showcases medical advances AP

ATLANTA – Cancer will overtake heart disease as the world's top killer by 2010, part of a trend that should more than double global cancer cases and deaths by 2030, international health experts reported Tuesday.

Rising tobacco use in developing countries is believed to be a huge reason for the shift, particularly in China and India, where 40 percent of the world's smokers now live.

So is better diagnosing of cancer, along with the downward trend in infectious diseases that used to be the world's leading killers.

Cancer diagnoses around the world have steadily been rising and are expected to hit 12 million this year. Global cancer deaths are expected to reach 7 million, according to the new report by the World Health Organization.

An annual rise of 1 percent in cases and deaths is expected — with even larger increases in China, Russia and India. That means new cancer cases will likely mushroom to 27 million annually by 2030, with deaths hitting 17 million.

Underlying all this is an expected expansion of the world's population — there will be more people around to get cancer.

The report is being released Tuesday by the WHO's International Agency for Research on Cancer at a news conference with officials from the American Cancer Society, the Lance Armstrong Foundation, Susan G. Komen for the Cure and the National Cancer Institute of Mexico.

The "unprecedented" gathering of organizations is an attempt to draw attention to the global threat of cancer, which isn't recognized as a major, growing health problem in some developing countries, said John Seffrin, the cancer society's chief executive officer.

The organizations are issuing a call to action, asking the U.S. government to help fund cervical cancer vaccinations and to ratify an international tobacco control treaty.

"If we take action, we can keep the numbers from going where they would otherwise go," Seffrin said.

Other groups are also voicing support for more action.

"Cancer is one of the greatest untold health crises of the developing world," said Dr. Douglas Blayney, president-elect of the American Society of Clinical Oncology.

"Few are aware that cancer already kills more people in poor countries than HIV, malaria and tuberculosis combined. And if current smoking trends continue, the problem will get significantly worse," he said in a statement.

___

On the Net:

The WHO's IARC: http://www.iarc.fr

The American Cancer Society: http://www.cancer.org

-----

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Health news and Funny Stuffs

2008-12-03T18:12:00.001-08:00

Health News

Study raps Web sites touting stem cell therapies

Enlarge Photo

Reuters

AP - Wed Dec 3, 3:10 PM ET

NEW YORK - Consumers should be wary of Web sites from clinics that offer stem cell treatments, says a study that found a lack of firm medical evidence to back up their claims. The Web sites in the study generally portrayed their therapies as safe, effective and ready for routine use, but published research doesn't support that "overoptimistic" picture, the study authors said.

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Fwd: New Lung Cancer Test Could Improve Early Detection (NBC 10 Philadelphia)

2008-11-30T13:51:00.000-08:00

---------- Forwarded message ----------
From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: New Lung Cancer Test Could Improve Early Detection (NBC 10 Philadelphia)
To: mesothelioma77@gmail.com

Scientists in the local area have developed a prototype test that could catch lung cancer before it kills.

Mon, 25 Aug 2008 19:36:18 GMT

___
Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=127en08ng/*http%3A//www.nbc10.com/health/17290079/detail.html?rss=phi&psp=health
--

--------

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Fwd: Nuclear factor kappa B: A marker of chemotherapy for human stage IV gastric carcinoma.

2008-11-09T05:49:00.001-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: Nuclear factor kappa B: A marker of chemotherapy for human stage IV gastric carcinoma.
To: mesothelioma77@gmail.com

[1]World J Gastroenterol. 2008 Aug 14; 14(30): 4739-44
Long YM, Ye S, Rong J, Xie WR

AIM: To detect the nuclear factor kappa B (NF-kappaB) condition in human stage IV gastric carcinoma patients and to explore the correlation between NF-kappaB activation and survival of these patients after chemotherapy. METHODS: Expression of NF-kappaB-p65 was determined by immunohistochemical analysis. Activity of NF-kappaB DNA-binding in carcinoma tissue was detected by electrophoretic mobility shift assay. Kaplan-Meier survival analysis was performed to show the relation between NF-kappaB and progression-free survival (PFS) or overall survival (OS) of the patients. RESULTS: The positive expression rate of NF-kappaB-p65 in 60 gastric cancer tissue samples was 76.7% (46/60). The expression of NF-kappaB-p65 was reduced in adjacent carcinoma and normal tissue samples. Electrophoretic mobility shift assay (EMSA) analysis showed a strong activation of NF-kappaB in cancer tissue samples. A survival difference was found in NF-kappaB-p65 positive and negative patients. NF-kappaB-p65 expression was negative in cancer tissue samples (n = 14). PFS was 191.40 +/- 59.88 d and 152.93 +/- 16.99 d, respectively, in patients with positive NF-kappaB-p65 expression (n = 46) (P = 0.4028). The survival time of patients with negative and positive NF-kappaB-p65 expression was 425.16 +/- 61.61 d and 418.85 +/- 42.98 d, respectively (P = 0.7303). Kaplan-Meier analysis showed no significant difference in PFS or OS. The 46 patient tissue which positive NF-kappaB-p65 expression was found in the tissue samples from the 46 patients whose PFS and OS were 564.89 +/- 75.94 d and s 352.37 +/- 41.32 d, respectively (P = 0.0165). CONCLUSION: NF-kappaB is activated in gastric carcinoma tissue, which is related to the OS after chemotherapy.

___
Source: http://www.hubmed.org/display.cgi?uids=18720533
--

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Fwd: OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models.

2008-11-09T05:48:00.003-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models.
To: mesothelioma77@gmail.com

[1]World J Gastroenterol. 2008 Aug 14; 14(30): 4800-4
Shi J, Wei PK, Zhang S, Qin ZF, Li J, Sun DZ, Xiao Y, Yu ZH, Lin HM, Zheng GJ, Su XM, Chen YL, Liu YF, Xu L

AIM: To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique. METHODS: Using OB glue paste technique, orthtopic transplantation models were established by implanting SGC-7901 and MKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed. RESULTS: The success rates of orthotopic transplan-tation of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%. CONCLUSION: OB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors.

___
Source: http://www.hubmed.org/display.cgi?uids=18720543
--

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Fwd: Gastric cancer cell lines induced by trichostatin A.

2008-11-09T05:48:00.001-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: Gastric cancer cell lines induced by trichostatin A.
To: mesothelioma77@gmail.com

[1]World J Gastroenterol. 2008 Aug 14; 14(30): 4810-5
Zou XM, Li YL, Wang H, Cui W, Li XL, Fu SB, Jiang HC

AIM: To explore the effect of trichostatin A (TSA) on apoptosis and acetylated histone H3 levels in gastric cancer cell lines BGC-823 and SGC-7901. METHODS: The effect of TSA on growth inhibition and apoptosis was examined by MTT, fluorescence microscopy and PI single-labeled flow cytometry. The acetylated histone H3 level was detected by Western blot. RESULTS: TSA induced apoptosis in gastric cancer cell lines BGC-823 and SGC-7901 was in a dose and time-dependent manner. Apoptotic cells varied significantly between TSA treated groups (37.5 ng/mL 72 h for BGC-823 cell line and 75 ng/mL 72 h for SGC-7901 cell line) and control group (0.85 +/- 0.14 vs 1.14 +/- 0.07, P = 0.02; 0.94 +/- 0.07 vs 1.15 +/- 0.06, P = 0.02). Morphologic changes of apoptosis, including nuclear chromatin condensation and fluorescence strength, were observed under fluorescence microscopy. TSA treatment in BGC-823 and SGC-7901 cell lines obviously induced cell apoptosis, which was demonstrated by the increased percentage of sub-G1 phase cells, the reduction of G1-phase cells and the increase of apoptosis rates in flow cytometric analysis. The result of Western blot showed that the expression of acetylated histone H3 increased in BGC-823 and SGC-7901 TSA treatment groups as compared with the control group. CONCLUSION: TSA can induce cell apoptosis in BGC-823 and SGC-7901 cell lines. The expression of acetylated histone H3 might be correlated with apoptosis.

___
Source: http://www.hubmed.org/display.cgi?uids=18720545
--

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Fwd: Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.

2008-11-07T17:39:00.003-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.
To: mesothelioma77@gmail.com

[1]Genes Chromosomes Cancer. 2008 Aug 21;
Loo LW, Ton C, Wang YW, Grove DI, Bouzek H, Vartanian N, Lin MG, Yuan X, Lawton TL, Daling JR, Malone KE, Li CI, Hsu L, Porter PL

The two main histological types of infiltrating breast cancer, lobular (ILC) and the more common ductal (IDC) carcinoma are morphologically and clinically distinct. To assess the molecular alterations associated with these breast cancer subtypes, we conducted a whole-genome study of 166 archival estrogen receptor (ER)-positive tumors (89 IDC and 77 ILC) using the Affymetrix GeneChip(R) Mapping 10K Array to identify sites of loss of heterozygosity (LOH) that either distinguished, or were shared by, the two phenotypes. We found single nucleotide polymorphisms (SNPs) of high-frequency LOH (>50%) common to both ILC and IDC tumors predominately in 11q, 16q, and 17p. Overall, IDC had a slightly higher frequency of LOH events across the genome than ILC (fractional allelic loss = 0.186 and 0.156). By comparing the average frequency of LOH by chromosomal arm, we found IDC tumors with significantly (P 25% informativity), we identified 78 and 466 individual SNPs with a higher frequency of LOH (P

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Source: http://www.hubmed.org/display.cgi?uids=18720524
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Fwd: Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer.

2008-11-07T17:39:00.001-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer.
To: mesothelioma77@gmail.com

[1]Genes Chromosomes Cancer. 2008 Aug 21;
Poonepalli A, Banerjee B, Ramnarayanan K, Palanisamy N, Putti TC, Hande MP

A study was undertaken to correlate telomere dysfunction and genomic instability with the histopathological grades and the estrogen and progesterone receptor status in breast cancer. Sixty-one archived breast tissues (38 cancer tissues and 23 paired normal tissues) were used in the study. The breast tumor tissues showed significantly shorter telomeres (7.7 kb) compared with the paired adjacent tissues (9.0 kb) by Southern blot analysis. Moreover, telomere shortening was more significant in Grade III tumors than in the Grade II tumors (P = 0.05). Quantitative fluorescence in situ hybridization on paraffin tissue sections revealed a similar trend in telomere shortening. Telomere attrition was associated with telomere dysfunction as revealed by the presence of significantly higher anaphase bridges in tumor cells which was tumor grade dependent. Furthermore, estrogen receptive negative tumors displayed higher anaphase and internuclear bridges. Selected samples from each grade showed greater genomic imbalances in the higher grades than the lower grade tumors as detected by array-comparative genomic hybridization. Telomerase activity was found to be higher in the higher grades (Grade II and III) compared with the lower grade (Grade I). The average mRNA expression of TRF1 and POT1 was lower in the tumor tissues than in the normal tissues. Tankyrase 1 mRNA expression showed a grade-dependent increase in tumor tissues and its expression was also high in estrogen and progesterone negative tumors. The data support the notion that telomere dysfunction might be of value as a marker of aggressiveness of the tumors in breast cancer patients. (c) 2008 Wiley-Liss, Inc.

___
Source: http://www.hubmed.org/display.cgi?uids=18720522
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Freshen Up Your Day. Watch and Upload Some of Your Humor and Funny Stuffs, Funny Videos At aseanface.com.

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We took our hearts' full pleasure—You and I,

And now the white sails of our ship are furled,

And spent the lading of our argosy.

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Funny Tagalog Quotes and funny prosper poems as well as Really Funny Quick Jokes can mildly be found on the internet.

Will no one tell me what she sings?–

Perhaps the plaintive numbers flow

For old, unhappy, far-off things,

And battles long ago:

Or is it some more classic lay,

Familiar matter of to-day?

Some natural sorrow, loss, or pain,

That has been, and may be again?

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How about you?

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Fwd: An Update on Cancer in American Indians and Alaska Natives, 1999-2004.

2008-11-07T17:38:00.001-08:00

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 28, 2008 at 6:28 AM
Subject: An Update on Cancer in American Indians and Alaska Natives, 1999-2004.
To: mesothelioma77@gmail.com

[1]Cancer. 2008 Aug 21; 113(S5): i-xiv

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Source: http://www.hubmed.org/display.cgi?uids=18720526
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Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc

Freshen Up Your Day. Watch and Upload Some of Your Humor and Funny Stuffs, Funny Videos At aseanface.com.

Do You Like Really Funny Quick Jokes

Good thing I'm full of joy

You were found in bed last night

With a professor named Roy..

Funny plays sketches free skits UK and Really Funny Quick Jokesas well as funny nicknames for girls are one of the chosen humor that perfectly people use these days.

We took our hearts' full pleasure—You and I,

And now the white sails of our ship are furled,

And spent the lading of our argosy.

At lunch time, sit in your parked car and point a hair dryer at passing cars to know if they slow down. Page yourself over the intercom. (Don't disguise your voice.)

Funny Tagalog Quotes and funny prosper poems as well as Really Funny Quick Jokes can mildly be found on the internet.

Will no one tell me what she sings?–

Perhaps the plaintive numbers flow

For old, unhappy, far-off things,

And battles long ago:

Or is it some more classic lay,

Familiar matter of to-day?

Some natural sorrow, loss, or pain,

That has been, and may be again?

Funny Goodbye Letters and Funny Sick Twisted Humor are my favourites.

How about you?

For more of your Humor and Funny Stuffsand Funny VideosInfo and Tips, Use this links and Enjoy the Entertainment from Our Selection Of Funny Videos...

Take away all your financial problems and….

LIVE THE LIFE YOU WANT!!! Have Some fun and Enjoy What life has to Offer...

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Here are some site and links you may need to go to in case you need more info and join the fun with social networking sites.

Freshen Your Day. Watch and Upload Some Of Your Humor And Funny Stuffs, Funny Videos

More Links and Info Sites For Your Searches

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I Need Some Funny Jokes Riddles For Teenagers, Really Funny Quick Jokes

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