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Friday, February 29, 2008

Fw: Rate of thromboembolic events in mesothelioma.



----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, February 23, 2008 10:57:15 PM
Subject: Rate of thromboembolic events in mesothelioma.

[1]Ann Thorac Surg. 2008 Mar; 85(3): 1032-8
Nguyen D, Lee SJ, Libby E, Verschraegen C

BACKGROUND: Thromboembolic event (TEE) rates in the general population and the cancer population are 0.1% to 2% and 10% to 15%, respectively. Our clinical observation is that mesothelioma patients are very susceptible to TEE, including arterial thromboses, but the TEE incidence has not been reported. This retrospective study attempts to determine the rates of TEE in patients with mesothelioma. METHODS: Three hundred seventy-four patients with mesothelioma were identified through the New Mexico SEER database. Sixty-five of them were included in the University of New Mexico tumor registry from 1973 to 2003. Documented TEE rates were abstracted from the patient charts. Chi-square test, Fisher's exact test, and logistic regression were used to identify potentially associated prognostic factors. RESULTS: Fifty-four medical records were reviewed. Patients had a median of six visits (range, 1 to 63 visits). Median age was 60 years (range, 29 to 79 years). Sex distribution was 11 women and 43 men. Anatomic locations of the primary tumor were 35 pleural, 17 peritoneal, 1 pericardial, and 1 pericardial or pleural mesothelioma. The TEE rate was 27.7% (15 of 54), including 10 deep venous thromboses, 2 arterial clots, 2 myocardial infarctions, and 1 pulmonary embolus. No association between the development of TEE and any known prognostic factors were observed. CONCLUSIONS: The 27.7% TEE incidence rate in mesothelioma patients is higher than in other cancer patients. The true incidence of TEE in mesothelioma is likely to be higher than the rate observed in our review, owing to the retrospective nature of the data. Prophylactic anticoagulation trials are recommended to determine the prevention benefit in this high-risk population.



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Source: http://www.hubmed.org/display.cgi?uids=18291192
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Fw: Anxiety Disorders, National Mental Health Information Center



----- Forwarded Message ----
From: CounsellingResource.com Search: mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, February 21, 2008 5:06:44 PM
Subject: Anxiety Disorders, National Mental Health Information Center

...Health Information Center. Contents What are anxiety disorders? Generalized Anxiety Disorder symptoms diagnosis treatment Panic Disorder symptoms diagnosis treatment Phobias symptoms diagnosis treatment Post-traumatic Stress...



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Source: http://counsellingresource.com/distress/anxiety-disorders/anxiety-nmhic.html
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Fwd: Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDO.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDO.
To: mesothelioma77@gmail.com


[1]Cell Cycle. 2008 Feb 7; 7(5):
Alabran JL, Cheuk A, Liby K, Sporn M, Khan J, Letterio J, Leskov KS

Synthetic triterpenoids, such as 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its derivatives, are an extremely potent class of new anti-cancer therapeutic agents, characterized by high antitumor potency and low toxicity to normal tissues. This report is the first to investigate the effects of C-28 derivatives of CDDO on 22 pediatric solid tumor cell lines, including neuroblastoma, rhabdomyosarcoma, osteosarcoma, and Ewing's sarcoma. We determined IC50s in the range of 5 - 170 nM for inhibition of colony formation and DNA synthesis, and 110 - 630 nM for metabolic cell death and decrease in cell number, using the C-28 CDDO analogs, CDDO methyl ester (CDDO-Me), CDDO imidazolide (CDDOIm), CDDO ethyl amide (CDDO-EA), CDDO trifluoroethyl amide (CDDO-TFEA), and CDDO diethylamide (CDDO-DE). After treatment of human neuroblastoma cells with CDDO-Me, cell cycle studies show depletion of the S-phase, while apoptosis studies show conformational activation and mitochondrial translocation of Bax protein, as well as activation of caspases -3 and -8. These data demonstrate the potential utility of CDDO analogs as promising novel therapeutic agents for high-risk pediatric solid tumors.



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Source: http://www.hubmed.org/display.cgi?uids=18277094
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Fwd: Meth, long the scourge of rural America, finally seeps into pop culture



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Meth, long the scourge of rural America, finally seeps into pop culture
To: mesothelioma77@gmail.com


So he turned to the ugliest thing he could think of: methamphetamine.The result is the new AMC series "Breaking Bad," where Gilligan's chemistry teacher protagonist, broke and dying of lung cancer, decides to ...

Fri, 15 Feb 2008 00:17:00 GMT


Source: http://www.topix.com/search/article?q=lung+cancer#Meth%2C+long+the+scourge+of+rural+America%2C+finally+seeps+into+pop+culture
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Fwd: Should Doctors Advocate Alternative Sources of Nicotine?



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Should Doctors Advocate Alternative Sources of Nicotine?
To: mesothelioma77@gmail.com


Should doctors suggest alternative sources of nicotine to people who are unable to give up cigarettes, asks this week's BMJ? Smoking currently kills over 100,000 UK citizens each year, predominantly from lung ...

Fri, 15 Feb 2008 00:05:00 GMT


Source: http://www.newswise.com/articles/view/537750/?sc=rsmn
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Fwd: Each Cigarette You Take A Chance



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Each Cigarette You Take A Chance
To: mesothelioma77@gmail.com


Valentine's Day is Meant for lovers so maybe you're thinking about having a cigarette after a holiday snuggle.

Fri, 15 Feb 2008 01:14:21 GMT


Source: http://www.rnews.com/Story_2004.cfm?ID=58308&rnews_story_type=18
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Fwd: Read the whole story



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Read the whole story
To: mesothelioma77@gmail.com


The Centers is Hiring! CFCC Is Hiring! '> Featured Jobs Hospice is Hiring Various Positions! The Centers is Hiring! CFCC Is Hiring! CFCC Is Hiring! The Centers is Hiring! Education links Being green In Jennifer ...

Fri, 15 Feb 2008 01:36:18 GMT


Source: http://www.chronicleonline.com/cgi-bin/storyviewxqwerty.cgi?071+OpinionEditorial.2008214-120-071-071011.Lead+
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