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Sunday, March 16, 2008

Fwd: Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer.



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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: Surgical Complications and the Risk Factors of Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer.
To: mesothelioma77@gmail.com


[1]Ann Surg Oncol. 2008 Mar 14;
Ryu KW, Kim YW, Lee JH, Nam BH, Kook MC, Choi IJ, Bae JM

BACKGROUND: Information on surgical complications of laparoscopy-assisted distal gastrectomy (LADG) and their risk factors is limited in the literature despite increasing popularity of this procedure. This study was performed to identify the surgical complications and their associated risk factors of LADG in early gastric cancer. METHODS: LADG was performed in 347 gastric cancer patients from January 2002 to December 2006 at the Korean National Cancer Center by four surgeons with ample experience of open gastric surgery before LADG. LADG indications for cases of gastric cancer at our institution are preoperatively diagnosed cT1N0 or cT1N1, except in cases with an absolute indication for endoscopic resection. Lymph node dissection of more than D1 + beta was performed in all patients. Intraoperative and postoperative complications were reviewed and their risk factors were retrospectively analyzed by prospective database information. RESULTS: Forty complications occurred in 34 patients (9.8%), but there was no mortality. Intraoperative complications occurred in nine patients (2.6%), and open conversion was performed in eight (2.3%) of these patients. Early and late postoperative complications occurred in 21 (6.1%) and 10 (2.9%) patients, respectively. The most serious complication was vascular injury resulting in bleeding or organ ischemia, which occurred in seven patients. Degree of lymph node dissection and surgical inexperience were found to be risk factors of surgical complication (P = .023, odds ratio 2.832, 95% confidence interval 1.155-6.946 vs. P = .028, odds ratio 2.975, 95% confidence interval 1.127-7.854). CONCLUSIONS: Lymph node dissection during LADG should be performed cautiously to prevent surgical complications like vascular injuries, especially during the surgeon's early learning period.



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Source: http://www.hubmed.org/display.cgi?uids=18340493
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Fwd: A multifunctional androgen receptor screening assay using the high-throughput Hypercyt((R)) flow cytometry system.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: A multifunctional androgen receptor screening assay using the high-throughput Hypercyt((R)) flow cytometry system.
To: mesothelioma77@gmail.com


[1]Cytometry A. 2008 Mar 13;
Dennis MK, Bowles HJ, Mackenzie DA, Burchiel SW, Edwards BS, Sklar LA, Prossnitz ER, Thompson TA

The androgen receptor (AR) is a steroid hormone receptor which regulates transcription of androgen-sensitive genes and is responsible for the development and maintenance of male secondary sexual characteristics. Chemicals that interfere with AR activity may lead to pathological conditions in androgen-sensitive tissues. A variety of reporter systems have been developed, driven by androgen-sensitive promoters, which screen for chemicals that modulate androgenic activity. We have developed a flexible, high-throughput AR transcriptional activation assay, designated the Multifunctional Androgen Receptor Screening (MARS) assay, to facilitate the identification of novel modulators of AR transcriptional activity using flow cytometry. Androgen-independent human prostate cancer-derived PC3 cells were transiently cotransfected with an expression vector for the wild-type human AR and an androgen-sensitive promoter regulating the expression of destabilized enhanced GFP (dsEGFP). The transfected cells were stimulated with established androgenic and antiandrogenic compounds and assessed for increased or decreased dsEGFP expression. To screen for antagonists of AR transcription, the AR agonist R1881 was coadministered at submaximal concentrations with potential AR antagonists. The assay was formatted for high-throughput screening using the HyperCyt(R) flow cytometry system. Agents with established androgenic and antiandrogenic activity were used for validation of the MARS assay. AR agonists were found to potently induce dsEGFP. Furthermore, AR agonists induced dsEGFP expression in a dose-dependent manner. Alternatively, AR antagonists blocked dsEGFP expression when coadministered with low-dose R1881, which also occurred in a dose-dependent manner. Modulators of AR transcriptional activity can be successfully identified by the MARS assay, utilizing a rapid, flexible, sensitive, and high-throughput format. Dose-response curves can be successfully generated for these compounds, allowing for an assessment of potency. Because of its simplicity and high-throughput compatibility, the MARS assay and HyperCyt(R) system combined with flow cytometric analysis represents a valuable and novel addition to the current repertoire of AR transcriptional activation screening assays. (c) 2008 International Society for Analytical Cytology.



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Source: http://www.hubmed.org/display.cgi?uids=18340645
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Fwd: Check on Welsh schools demanded after ex-teacher’s asbestos death (icWales)



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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:56 AM
Subject: Check on Welsh schools demanded after ex-teacher's asbestos death (icWales)
To: mesothelioma77@gmail.com


ALL schools in Wales must be checked for asbestos after the death of a retired teacher was linked to the carcinogenic building material, teachers' leaders and the Welsh Assembly Government said yesterday.

Sat, 15 Mar 2008 06:57:00 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/asbestos+cancer/SIG=14fv6abut/*http%3A//icwales.icnetwork.co.uk/news/wales-news/2008/03/15/check-on-welsh-schools-demanded-after-ex-teacher-s-asbestos-death-91466-20626591/
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Fwd: Checkoff numbers cause for concern?



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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sun, Mar 16, 2008 at 1:55 AM
Subject: Checkoff numbers cause for concern?
To: mesothelioma77@gmail.com


Tri-state taxpayers share the experience of cutting a check to Uncle Sam or getting a return this time of year, but thousands of them also use their income tax filing to boost worthy causes.

Sat, 15 Mar 2008 16:05:57 GMT


Source: http://www.THonline.com/article.cfm?id=194525
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