Skin Cancer Charts Graphs: 10/07/08

Tuesday, October 7, 2008

Fwd: Recurrence of Anal Adenocarcinoma After Local Excision and Adjuvant Chemoradiation Therapy: Report of a Case and Review of the Literature.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Sep 24, 2008 at 1:30 PM
Subject: Recurrence of Anal Adenocarcinoma After Local Excision and Adjuvant Chemoradiation Therapy: Report of a Case and Review of the Literature.
To: mesothelioma77@gmail.com

[1]J Gastrointest Surg. 2008 Sep 23;
Lee J, Corman M

INTRODUCTION: Tumors arising from the anal canal are rare, comprising 1.5% of all gastrointestinal tumors in the USA. The vast majority of these anal cancers are epidermoid (cloacogenic/basaloid and squamous cell carcinomas), while adenocarcinomas reportedly occur 5% to 19% of the time. Because of its rarity, reports about anal adenocarcinoma are limited to small retrospective studies and case reports. Moreover, no series has directly compared outcomes between patients undergoing the various available treatment options, making it difficult to determine the optimal treatment for this aggressive cancer. Current management of this cancer remains controversial, with some authors believing abdominoperineal resection with permanent colostomy should be considered the standard treatment. Others propose that combined chemoradiation be adopted as a possible treatment in certain patients. CASE PRESENTATION: We describe a case of recurrent anal adenocarcinoma after conservative management with local excision and adjuvant chemoradiation therapy.

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Source: http://www.hubmed.org/display.cgi?uids=18810561
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Fwd: Changes of the metabolism of the colon cancer cell line SW-480 under serum-free and serum-reduced growth conditions.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Sep 24, 2008 at 1:30 PM
Subject: Changes of the metabolism of the colon cancer cell line SW-480 under serum-free and serum-reduced growth conditions.
To: mesothelioma77@gmail.com

[1]In Vitro Cell Dev Biol Anim. 2008 Sep 23;
Hartmann M, Zimmermann D, Nolte J

Serum of animal origin, like foetal calf serum (FCS), is used as a standard supplement for media to cultivate mammalian cells, mostly due to its growth-supporting properties. Unfortunately, animal serum has many disadvantages like the risk of contamination, high costs, fluctuations within the composition of different batches and the high amount of foetuses, which have to be harvested. To avoid all this, it is necessary to provide alternatives, which combine as many positive properties of the animal serum as possible but do not influence the cellular metabolism negatively. Today, several serum-free complete media as well as serum substitutes are commercially available. In the present study, a serum substitute, a serum-reduced medium and a serum-free medium were evaluated concerning their influence on the metabolism on the colon cancer cell line SW-480. The evaluation of morphological changes of the cells was done by microscopic analysis whereas differences in the volatile metabolome were analysed by solid phase micro extraction (SPME) followed by gas chromatography/mass spectrometry (GC/MS).

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Source: http://www.hubmed.org/display.cgi?uids=18810564
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Fwd: Proficiency-gain curve for an advanced laparoscopic procedure defined by observation clinical human reliability assessment (OCHRA).

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Sep 24, 2008 at 1:30 PM
Subject: Proficiency-gain curve for an advanced laparoscopic procedure defined by observation clinical human reliability assessment (OCHRA).
To: mesothelioma77@gmail.com

[1]Surg Endosc. 2008 Sep 23;
Talebpour M, Alijani A, Hanna GB, Moosa Z, Tang B, Cuschieri A

BACKGROUND: There is no established method for defining when a surgeon reaches the proficiency plateau in performing a specific operation. The published literature refers to "learning curves" based on retrospective evaluation of operative time, conversion rates, morbidity etc., which lack objectivity and do not address individual human factors. A more useful study of the gain in proficiency by the individual surgeon for a particular operation may be obtained using observational clinical-human reliability assessment (OCHRA). METHODS: Following an 8-month fellowship in advanced laparoscopic surgery, the surgeon M.T. performed, independently at his own hospital, a prospective series of 20 palliative bypass operations for advanced gastric or pancreatic cancer. Unedited videotapes of gastro-jejunostomy (GJ) or cholecysto-jejunostomy (CJ) were analyzed independently in the training institution by the OCHRA technique. RESULTS: For this surgeon proficiency in executing laparoscopic palliative bypass was reached after the 14th anastomosis when efficient execution (reduction in operative time) was accompanied by significant reduction in technical errors and improved economy of movement (reduction of the economy of movement index from 7-5 to 3-2). The majority of errors were enacted in component tasks associated with intracorporeal suturing. The declining incidence of these errors with experience was an integral component of the proficiency-gain curve. The important performance-shaping factors identified were: concentration lapses (n = 1,321), misjudgments (n = 209), poor camera work (n = 193), fatigue (n = 128), and impaired coordination (n = 108). CONCLUSIONS: This study has confirmed that OCHRA can describe quantitatively the proficiency-gain curve for a laparoscopic operation and indicate the plateau stage when the individual surgeon attains maximal performance in the execution of a specific procedure.

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Source: http://www.hubmed.org/display.cgi?uids=18810544
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