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Thursday, March 20, 2008

Mesothelioma Cancer: The Deadly Cancer

Unlike lung cancer, there is no association between mesothelioma and smoking Mesothelioma is a wizardry of cancer that is almost always caused by previous exposure to asbestos Mesothelioma is the word used to describe a cancerous tumor that involves the mesothelial cells of an organ, often the lungs, heart, or abdominal organs. Its greatest easily understood site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

Surpassingly people who develop mesothelioma get hold of worked on jobs where they inhaled asbestos particles, or carry been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products. It can also occur in children; however, these cases are not thought to be associated with asbestos exposure.

Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity).  A history of exposure to asbestos may increase clinical suspicion for mesothelioma. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. This is the end of a expertise that usually begins with symptoms that send most people to the doctor: a fluid build-up around the lungs (pleural effusions), shortness of breath, suffering in the chest, or suffering or swelling in the abdomen.

 A physical examination is performed, followed by chest X-ray and often lung function tests. Shortness of breath, cough, and aches and in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

 If the cancer has body beyond the mesothelium to other parts of the spread, symptoms may include aches and, trouble swallowing, or swelling of the neck or make contact with.

Tissue is removed, placed under the microscope, and a pathologist makes a definitive diagnosis, and issues a pathology report. Malignant mesothelioma is a rare type of cancer in which malignant cells are found in the sac lining the chest or abdomen. Extremely malignant mesotheliomas accept complex karyotypes, with extensive aneuploidy and rearrangement of swarms chromosomes. 

Most people with malignant mesothelioma require worked on jobs where they breathed asbestos. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.

 Malignant mesothelioma has a peak incidence 35-45 years after asbestos exposure. Malignant mesothelioma has also been linked to remedial radiation using thorium dioxide and zeolite, a silicate in the soil.

Malignant mesothelioma is often just called simply Mesothelioma and is a form of lung cancer that is quite rare.

Malignant mesothelioma is more explicit in men, with a male-to-female ratio of 3:1. In this disease, malignant cells develop in the mesothelium, a protective lining that covers extremely of the body's internal organs.

The be obliged of radiation therapy in pleural mesothelioma has been shown to alleviate aches and in the majority of patients that are treated. But unfortunately, the duration of symptom control is short-lived. Radiation has no effect on survival, but it has caused significant palliation in 50% of patients treated for chest aches and and chest wall metastasis. There are now a number of cancer treatment options open to mesothelioma victims. Extrapleural pneumonectomy for selected victims with very early stage disease may extend recurrence-free survival, but the impact it has on overall survival is unknownat this time.

Surgical resection has been relied upon because radiation and chemotherapy set up been ineffective legitimate treatments. The 2 surgical procedures used are pleurectomy with decortication and extrapleural pneumonectomy.
 
Ling Ling
 

Fwd: Psychological and clinical factors implicated in decision making about a trial of low-dose tamoxifen in hormone replacement therapy users.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 20, 2008 at 10:08 AM
Subject: Psychological and clinical factors implicated in decision making about a trial of low-dose tamoxifen in hormone replacement therapy users.
To: mesothelioma77@gmail.com


[1]J Clin Oncol. 2008 Mar 20; 26(9): 1537-43
Rondanina G, Puntoni M, Severi G, Varricchio C, Zunino A, Feroce I, Bonanni B, Decensi A

PURPOSE To assess the sociodemographic, health-related, and psychological factors that influence the decision of women on hormone replacement therapy (HRT) to participate in a phase III trial of low-dose tamoxifen. PATIENTS AND METHODS Clinical and psychological factors were assessed in 265 women who accepted and 192 women who refused to participate in a proposed trial. Health-related and sociodemographic factors included age, Gail risk, body mass index, education, current HRT use, regular mammographic screening, smoking habit, physical activity, alcohol use, concern about adverse effects, and physician recommendation. Psychological factors included breast cancer-related worry, absolute and comparative cancer risk perception, anxiety, and depression. Results The most frequent reasons for entry were willingness to participate in a research program (60%), the need/desire to receive frequent medical care (58%), and the desire to contribute to medical knowledge (44%); whereas reasons for refusal included fear of medication abuse (33%), concern about adverse effects (31%), and physician advice against enrollment (24%). In a logistic model, after adjusting for current HRT use, the trial participation was directly associated with satisfaction with clearly explained study objectives (odds ratio [OR] = 9.33; 95% CI, 4.04 to 21.55) and inversely associated with high breast cancer worry (OR = 0.15; 95% CI, 0.03 to 0.77) and age >/= 60 years (OR = 0.40; 95% CI, 0.22 to 0.73). CONCLUSION Participation in a chemoprevention trial among HRT users is associated with a younger age, no breast cancer worry, and satisfaction with health care providers, suggesting a condition of psychological well-being as a promoting factor and emphasizing the importance of thorough counseling at study presentation.



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Source: http://www.hubmed.org/display.cgi?uids=18349406
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Fwd: Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 20, 2008 at 10:08 AM
Subject: Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer.
To: mesothelioma77@gmail.com


[1]World J Gastroenterol. 2008 Mar 28; 14(12): 1931-5
Ai KX, Lu LY, Huang XY, Chen W, Zhang HZ

AIM: To investigate the expression of vascular endothelial growth factor (VEGF) and calcium-binding protein S100A4 in pancreatic cancer and their relationship to the clinicopathological parameters and prognosis of pancreatic cancer. METHODS: Expression status of VEGF and S100A4 was examined in 62 surgical specimens of primary pancreatic cancer by immunohistochemistry. Correlation between the expression of VEGF and S100A4 and clinicopathological parameters was analyzed. RESULTS: Thirty-eight of 62 (61.3%) specimens of primary pancreatic cancer were positive for S100A4. Thirty-seven (59.7%) specimens showed positive expression of VEGF. The positive correlation between S100A4 and VEGF expression was significant in cancer tissues (P

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Source: http://www.hubmed.org/display.cgi?uids=18350635
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Fwd: Integrative genome-wide expression analysis bears evidence of estrogen receptor-independent transcription in heregulin-stimulated mcf-7 cells.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 20, 2008 at 10:07 AM
Subject: Integrative genome-wide expression analysis bears evidence of estrogen receptor-independent transcription in heregulin-stimulated mcf-7 cells.
To: mesothelioma77@gmail.com


[1]PLoS ONE. 2008; 3(3): e1803
Nagashima T, Suzuki T, Kondo S, Kuroki Y, Takahashi K, Ide K, Yumoto N, Hasegawa A, Toyoda T, Kojima T, Konagaya A, Suzuki H, Hayashizaki Y, Sakaki Y, Hatakeyama M

Heregulin ss-1 (HRG) is an extracellular ligand that activates mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathways through ErbB receptors. MAPK and Akt have been shown to phosphorylate the estrogen receptor (ER) at Ser-118 and Ser-167, respectively, thereby mimicking the effects of estrogenic activity such as estrogen responsive element (ERE)-dependent transcription. In the current study, integrative analysis was performed using two tiling array platforms, comprising histone H3 lysine 9 (H3K9) acetylation and RNA mapping, together with array comparative genomic hybridization (CGH) analysis in an effort to identify HRG-regulated genes in ER-positive MCF-7 breast cancer cells. Through application of various threshold settings, 333 (326 up-regulated and 7 down-regulated) HRG-regulated genes were detected. Prediction of upstream transcription factors (TFs) and pathway analysis indicated that 21% of HRG-induced gene regulation may be controlled by the MAPK cascade, while only 0.6% of the gene expression is controlled by ERE. A comparison with previously reported estrogen (E2)-regulated gene expression data revealed that only 12 common genes were identified between the 333 HRG-regulated (3.6%) and 239 E2-regulated (5.0%) gene groups. However, with respect to enriched upstream TFs, 4 common TFs were identified in the 14 HRG-regulated (28.6%) and 13 E2-regulated (30.8%) gene groups. These results indicated that while E2 and HRG may induce common TFs, the regulatory mechanisms that govern HRG- and E2-induced gene expression differ.



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Source: http://www.hubmed.org/display.cgi?uids=18350142
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Fwd: Continued Drinking During Pregnancy More Likely To Continue Among African-American Women



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 20, 2008 at 10:07 AM
Subject: Continued Drinking During Pregnancy More Likely To Continue Among African-American Women
To: mesothelioma77@gmail.com


Main Category: Pregnancy / Obstetrics Also Included In: Women's Health / Gynecology Alcohol / Addiction / Illegal Drugs Article Date: 20 Mar 2008 A New Saint Louis University study has found that although ...

Thu, 20 Mar 2008 10:15:33 GMT


Source: http://www.medilexicon.com/medicalnews.php?newsid=101115
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Fwd: Another scandal



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 20, 2008 at 10:07 AM
Subject: Another scandal
To: mesothelioma77@gmail.com


'Environmental conditions are worse here, perhaps, than in any other part of the country.' Here's something you may find nearly as interesting, and a bit more significant, than the price of career-killing call ...

Thu, 20 Mar 2008 09:08:09 GMT


Source: http://www.metrotimes.com/editorial/story.asp?id=12648
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Health Wellness Sites and Info:

Health Wellness

Relieve Stress Anxiety Tensions Holiday Stress

Mind Body Yoga

Mesothelioma

Mesothelioma diagnosis: What You Need To Know

Daily Recommended Relaxation

Transcendental Meditation