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Fwd: Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and N

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Wed, Apr 2, 2008 at 2:27 AM
Subject: Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
To: mesothelioma77@gmail.com

[1]Carcinogenesis. 2008 Mar 28;
Dossus L, McKay JD, Canzian F, Wilkening S, Rinaldi S, Biessy C, Olsen A, Tjønneland A, Jakobsen MU, Overvad K, Clavel-Chapelon F, Boutrom-Ruault MC, Fournier A, Linseisen J, Lukanova A, Boeing H, Fisher E, Tricholpoulou A, Georgila C, Trichopoulos D, Palli D, Krogh V, Tumino R, Vineis P, Quirós JR, Sala N, Martínez-García C, Dorronsoro M, Chirlaque MD, Barricarte A, van Duijnhoven FJ, Bueno-de-Mesquita H, van Gils CH, Peeters PH, Hallmans G, Lenner P, Bingham S, Khaw KT, Key TJ, Travis RC, Ferrari P, Jenab M, Riboli E, Kaaks R

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) and breast cancer risk. Pairwise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (OR: 1.2; 95%CI: 1.0-1.4; P = 0.02). The GHRL SNP rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body-mass-index and height (P between

___
Source: http://www.hubmed.org/display.cgi?uids=18375957
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Fwd: Developing Novel Cancer Therapies and Understanding the Patient Outcomes

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Wed, Apr 2, 2008 at 2:26 AM
Subject: Developing Novel Cancer Therapies and Understanding the Patient Outcomes
To: mesothelioma77@gmail.com

There are four main types of cancer. About 85% are non-small cell types and the balance small cell, that often identifies lung cancer.

Wed, 02 Apr 2008 03:12:12 GMT

Source: http://w3w3.blogs.com/w3w3com/2008/04/developing-nove.html
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Fwd: Colorectal cancer screening practices of primary care physicians in washington state.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Apr 2, 2008 at 2:26 AM
Subject: Colorectal cancer screening practices of primary care physicians in washington state.
To: mesothelioma77@gmail.com

[1]Cancer Control. 2008 Apr; 15(2): 174-81
Hannon PA, Martin DP, Harris JR, Bowen DJ

BACKGROUND: Colorectal cancer screening reduces death from colorectal cancer, but screening rates are low. While research has identified barriers to screening from the patient perspective, less research has addressed screening from the physician perspective. METHODS: The Washington Comprehensive Cancer Control Partnership conducted a survey of primary care physicians in Washington State to measure their knowledge, attitudes, and practices for colorectal cancer screening of average-risk patients. The survey was mailed to a simple random sample of 700 primary care physicians in Washington State. Sixty-nine percent of the eligible physicians in the sample participated. RESULTS: Most respondents (76%) recommended one or more colorectal cancer screening tests in agreement with American Cancer Society guidelines, and 93% perceived patient anxiety about colorectal cancer screening tests to be a significant barrier to screening. Ninety percent of physicians reported using the fecal occult blood test (FOBT) as a screening test, but most did not report performing any tracking or using any mechanism to encourage their patients to complete and return FOBT kits. CONCLUSIONS: These findings suggest three intervention approaches to increase colorectal cancer screening in primary care settings: improve physicians' knowledge about current screening guidelines (especially appropriate age and screening intervals), encourage physicians to strongly recommend screening to patients, and help physicians adopt tracking systems to follow screening to completion.

___
Source: http://www.hubmed.org/display.cgi?uids=18376385
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