Fwd: Mesothelioma Cancer Mouse Model Reproduces Human Disease

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From: Live Search News: asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 13, 2008 at 11:35 AM
Subject: Mesothelioma Cancer Mouse Model Reproduces Human Disease
To: mesothelioma77@gmail.com


HULIQ.com - Scientists have established a mouse model for human malignant mesothelioma (MM) that will provide valuable insight ... reproduces human disease Talcum powder stunts growth of lung tumors Chemo combination improves survival in asbestos-related cancer

Tue, 11 Mar 2008 19:13:00 GMT

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Source: http://www.huliq.com/53288/mesothelioma-cancer-mouse-model-reproduces-human-disease
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Fwd: Pathway Analysis of Microarray Data via Regression.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 13, 2008 at 11:35 AM
Subject: Pathway Analysis of Microarray Data via Regression.
To: mesothelioma77@gmail.com


[1]J Comput Biol. 2008 Mar 10;
Adewale AJ, Dinu I, Potter JD, Liu Q, Yasui Y

Pathway analysis of microarray data evaluates gene expression profiles of a priori defined biological pathways in association with a phenotype of interest. We propose a unified pathway-analysis method that can be used for diverse phenotypes including binary, multiclass, continuous, count, rate, and censored survival phenotypes. The proposed method also allows covariate adjustments and correlation in the phenotype variable that is encountered in longitudinal, cluster-sampled, and paired designs. These are accomplished by combining the regression-based test statistic for each individual gene in a pathway of interest into a pathway-level test statistic. Applications of the proposed method are illustrated with two real pathway-analysis examples: one evaluating relapse-associated gene expression involving a matched-pair binary phenotype in children with acute lymphoblastic leukemia; and the other investigating gene expression in breast cancer tissues in relation to patients' survival (a censored survival phenotype). Implementations for various phenotypes are available in R. Additionally, an Excel Add-in for a user-friendly interface is currently being developed.



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Source: http://www.hubmed.org/display.cgi?uids=18331198
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Fwd: Lung metastases after liver resection or cryotherapy for hepatic metastasis from colorectal cancer-there is a difference!

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 13, 2008 at 11:35 AM
Subject: Lung metastases after liver resection or cryotherapy for hepatic metastasis from colorectal cancer-there is a difference!
To: mesothelioma77@gmail.com


[1]HPB (Oxford). 2006; 8(2): 124-31
Yan TD, Chiang G, Zhao J, Chan D, Morris DL

Background. The most common site of colorectal extra-abdominal metastases is the lung. The relative risk of lung metastases after resection and cryotherapy has not previously been compared. Methods. All patients underwent an extensive preoperative staging including clinical examination, abdominal computed tomography (CT) and abdominal angio-CT to assess their hepatic disease. Two groups of patients were compared in this study (hepatic resection alone and hepatic cryotherapy with or without resection). A retrospective analysis of prospectively collected data was performed to assess the incidence and disease-free interval of pulmonary metastasis after surgical treatment of colorectal liver metastasis. Results. This paper clearly shows two differences regarding pulmonary metastases between patients treated with resection only and cryotherapy with or without resection. Among the 10 clinical variables, cryotherapy had the greatest correlation with pulmonary metastases (p=0.004). A patient who undergoes hepatic resection only has a probability of 35% for developing pulmonary recurrence, compared with 51% following cryotherapy. Cryotherapy was also independently associated with shorter pulmonary disease-free interval (p=0.036). Conclusion. There clearly is a higher risk of pulmonary metastasis after cryotherapy than after resection, whether this is related to selection of patients or a direct deleterious procedural effect requires more study.



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Source: http://www.hubmed.org/display.cgi?uids=18333260
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Fwd: Liver resection for hepatic metastases from adrenocortical carcinoma.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Mar 13, 2008 at 11:35 AM
Subject: Liver resection for hepatic metastases from adrenocortical carcinoma.
To: mesothelioma77@gmail.com


[1]HPB (Oxford). 2006; 8(2): 106-9
Carlo ID, Toro A, Sparatore F, Cordio S

Liver metastases from adrenocortical carcinoma are very rare and no clear indications for surgery exist. The aim of the present work was to define surgical indications for these neoplasms. All the patients submitted to hepatic resection for liver metastases from adrenal carcinoma reported in the literature (PubMed source) from 1978 to 2005 were considered for the present study. Forty-eight patients were found in the period of study, but it was only possible to obtain certain data for nine patients (18.7%). The data investigated suggest that metachronous metastases, developed after a minimum of 1 year from the primary tumor, and completely removable, may represent an indication for surgery - although this still needs to be proved.



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Source: http://www.hubmed.org/display.cgi?uids=18333256
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