Skin Cancer Charts Graphs: 04/17/08

Thursday, April 17, 2008

Fwd: Aggressiveness of Cancer-Care near the End-of-Life in Korea.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Apr 17, 2008 at 4:36 AM
Subject: Aggressiveness of Cancer-Care near the End-of-Life in Korea.
To: mesothelioma77@gmail.com

[1]Jpn J Clin Oncol. 2008 Apr 14;
Keam B, Oh DY, Lee SH, Kim DW, Kim MR, Im SA, Kim TY, Bang YJ, Heo DS

OBJECTIVE: The aim of this study was to examine the appropriateness of chemotherapy and care in Korean cancer patients near the end-of-life. METHODS: We designed a retrospective cohort composed of patients diagnosed as having metastatic cancer and who received palliative chemotherapy at Seoul National University Hospital in 2002. Two hundred and ninety-eight patients who died of cancer were evaluated in terms of the appropriateness of the cancer-care they received, including chemotherapy. RESULTS: Median duration of chemotherapy was 6.02 months compared with 8.67 months for median overall survival. The median period between last chemotherapy and death was 2.02 months. Of the 298 patients, 50.3% received chemotherapy during the last 2 months of life. Furthermore, 17 patients (5.7%) died within 2 weeks after receiving chemotherapy. The proportion who visited an emergency room (ER) more than once during the last months of life was 33.6%, and the average number of ER visits after a diagnosis of cancer was 1.72. Only 9.1% of patients were referred to a hospice consultation service and only 11.7% of patients agreed with written DNR. CONCLUSIONS: Among patients who died of cancer, significant proportions were found to have received chemotherapy up to the end-of-life and to have visited ERs. Hospice referrals and discussions about DNR were not conducted well during the end-of-life period in Korea.

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Source: http://www.hubmed.org/display.cgi?uids=18411260
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Fwd: Molecular Evidence Demonstrating Local Treatment Failure is The Source of Distant Metastases in Some Patients Treated for Breast Cancer.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Apr 17, 2008 at 4:36 AM
Subject: Molecular Evidence Demonstrating Local Treatment Failure is The Source of Distant Metastases in Some Patients Treated for Breast Cancer.
To: mesothelioma77@gmail.com

[1]Int J Radiat Oncol Biol Phys. 2008 Apr 12;
Vicini FA, Goldstein NS, Wallace M, Kestin L

PURPOSE: To examine the clonality relationships among initial invasive breast carcinoma (IBC), ipsilateral breast failure (IBF), and distant metastasis (DM) to determine the effect of local tumor recurrence on the development of DMs. METHODS AND MATERIALS: A total of 18 patients treated with breast-conserving therapy who developed an IBF followed by DMs were studied using a 20 informative-marker, polymerase chain reaction-based allelic imbalance clonality assay. RESULTS: Four relationships were identified. First, in 7 cases, the IBF and DMs were clonally related to the initial IBC as one progressively genetic unstable process. Second, in 3 cases, the IBF and DMs were each clonally related to the IBC but clonally distinct from each other. Third, in 3 cases, the IBC and the IBF were clonally related and the DMs were clonally related to the IBFs, with a weak relationship to the initial IBC. Finally, in 5 cases, the IBF was clonally distinct from the initial IBC (new second primary) and the DMs were clonally related to the IBF and clonally distinct from the initial IBC. CONCLUSION: These findings provide molecular evidence demonstrating that some MDs can directly develop from IBFs and support the importance of local tumor control in the overall treatment of breast cancer patients.

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Source: http://www.hubmed.org/display.cgi?uids=18410995
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