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Saturday, March 29, 2008

Fwd: PIK3CA activating mutations and chemotherapy sensitivity in stage II-III breast cancer.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:46 PM
Subject: PIK3CA activating mutations and chemotherapy sensitivity in stage II-III breast cancer.
To: mesothelioma77@gmail.com


[1]Breast Cancer Res. 2008 Mar 27; 10(2): R27
Liedtke C, Cardone L, Tordai A, Yan K, Gomez HL, Barajas Figureoa LJ, Hubbard RE, Valero V, Souchon EA, Symmans WF, Hortobagyi GN, Bardelli A, Pusztai L

ABSTRACT: INTRODUCTION: In vitro evidence suggests that PIK3CA activation may be associated with altered chemotherapy sensitivity in cancer. METHODS: Tumor DNA from 140 patients with stage II-III breast cancer undergoing neoadjuvant chemotherapy was sequenced for PIK3CA mutations on exons 1, 9 and 20. Mutation status was correlated with clinical/pathological parameters and chemotherapy response as (i) pathological complete response [pCR] vs residual cancer or (ii) quantitative residual cancer burden (RCB) scores, including stratification for estrogen receptor (ER) expression status, type of chemotherapy and separate exons individually. RESULTS: 23 patients (16.4%) harbored a PIK3CA mutation, with 12, 11 and no mutation(s) located in exon 9, 20 and 1, respectively. PIK3CA exon 9 mutations were more frequent among node-negative (52% vs 25% p=0.012) compared to node-positive cancers, particularly among ER-positive tumors. pCR rates and RCB scores were similar among patients with wild type and mutant PIK3CA gene, even after stratification by ER-status, chemotherapy regimen (anthracycline- versus anthracycline plus paclitaxel) or exon. CONCLUSION: PIK3CA mutations are not associated with altered sensitivity to preoperative anthracycline- or taxane-based chemotherapies in ER-positive and ER-negative breast cancers. In this study, PIK3CA mutation was associated with a decreased rate of node-positive disease particularly among ER-positive cancers.



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Fwd: Current treatment of acute lower extremity deep venous thrombosis.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:45 PM
Subject: Current treatment of acute lower extremity deep venous thrombosis.
To: mesothelioma77@gmail.com


[1]Int J Low Extrem Wounds. 2008 Mar; 7(1): 15-20
Janjigian MP, Muhs BE

The long-term complications of acute deep venous thrombosis (DVT) include recurrence, increased mortality, and the development of the postthrombotic syndrome. Rates of recurrent venous thromboembolism (VTE) are elevated in patients with cancer and thrombophilia. Heparin, administered either as unfractionated or low-molecular weight, is indicated for at least five days for acute DVT. Long-term treatment is currently a vitamin K antagonist with a variable duration depending on the etiology of the DVT and risk of bleeding. Novel anticoagulant agents that target factor Xa and directly inhibit thrombin are being studied in clinical trials and may one day replace vitamin K antagonists for the long-term treatment of VTE.Interventional approaches such as percutaneous mechanical thrombectomy have the potential to reduce clot burden in acute DVT with lower bleeding risks and help prevent development of the postthrombotic syndrome, a common and potentially debilitating complication of DVT.



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Fwd: [Principles of oncoplastic surgery in breast surgery.]



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:46 PM
Subject: [Principles of oncoplastic surgery in breast surgery.]
To: mesothelioma77@gmail.com


[1]Ann Chir Plast Esthet. 2008 Mar 25;
Cothier-Savey I, Rimareix F

After a conservative treatment for breast cancer, 75% of patients end up with a good aesthetic result, i.e. little or no residual asymmetry and minor postradiotherapy after-effects. In 20 to 25% of cases, the conservative treatment leaves lasting after-effects associated with surgery and radiotherapy. Such aesthetic after-effects are difficult to treat and they require additional plastic surgery in 5 to 10% of cases. Oncoplastic surgery, which combines large lumpectomy and remodeling procedure involving different plastic surgery methods, improves these cosmetic results after a partial mastectomy and widens the scope for conservative treatment. Today, these techniques are well codified. They range from simple reshaping to more sophisticated techniques involving a concomitant controlateral-breast-symmetrisation procedure. These surgical options must be elaborated in detail with the patient and depend on the patient, the type of the tumor, its position, the ratio between the volume of the tumor and that of the breast and the overall care given by a multispecialist team. Plastic surgery is now an integral part of the treatment of breast cancer, hence the use of the word: oncoplastic surgery.



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Fwd: Tobacco Cash in Lung Study Stirs Flap



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:45 PM
Subject: Tobacco Cash in Lung Study Stirs Flap
To: mesothelioma77@gmail.com


More... More... More... Associated Press Writers The disclosure of hidden tobacco money behind a big study suggesting that lung scans might help save smokers from cancer has shocked the research community and ...

Thu, 27 Mar 2008 21:29:49 GMT


Source: http://www.daytondailynews.com/news/content/shared-gen/ap/Health_Medical/Research_Conflicts_Analysis.html?cxtype=rss&cxsvc=1&cxcat=0
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Fwd: Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:45 PM
Subject: Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease.
To: mesothelioma77@gmail.com


[1]Ann Oncol. 2008 Mar 27;
Prasad KN, Saxena A, Ghoshal UC, Bhagat MR, Krishnani N

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcription factor involved in various disease processes including inflammation and carcinogenesis. We investigated the association of Pro12Ala PPARgamma polymorphism and Helicobacter pylori infection with gastric cancer and peptic ulcer disease (PUD). PATIENTS AND METHODS: In total, 348 adult patients [62 gastric adenocarcinoma, 45 PUD and 241 nonulcer dyspepsia (NUD)] who underwent an upper gastrointestinal endoscopy were enrolled. PPARgamma polymorphism was analyzed by PCR-based restriction fragment length polymorphism. H. pylori infection was diagnosed by rapid urease test, culture, histopathology and PCR. RESULTS: PPARgamma G carrier had significant association with gastric adenocarcinoma [P = 0.023, odds ratio (OR) = 2.136, 95% CI = 1.112-4.104] and PUD (P = 0.028, OR = 2.165, 95% CI = 1.008-4.306) when compared with NUD. Combination of G carrier and H. pylori infection further increased the risk of gastric adenocarcinoma (OR = 3.054, 95% CI = 1.195-7.807) and PUD (OR = 11.161, 95% CI = 3.495-35.644). PPARgamma polymorphism did not increase the risk of gastric adenocarcinoma and PUD in H. pylori-negative subjects. CONCLUSIONS: The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.



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Source: http://www.hubmed.org/display.cgi?uids=18372284
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