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Friday, April 18, 2008

Fwd: Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.



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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.
To: mesothelioma77@gmail.com


[1]Scand J Gastroenterol. 2008; 43(5): 531-7
Saegusa Y, Ichikawa T, Iwai T, Goso Y, Ikezawa T, Nakano M, Shikama N, Saigenji K, Ishihara K

OBJECTIVE: Acid antisecretory agents are used for the prophylaxis of cancer chemotherapy (CT)-induced gastrointestinal (GI) mucositis. Although these drugs seem to be clinically beneficial, data on their effects on the GI mucosal defense during CT treatment are scant. The objective of this study was to compare the effects of omeprazole, lansoprazole, and lafutidine on mucin, a major mucus component, during 5-fluorouracil (5-FU) treatment, as a CT regimen. MATERIAL AND METHODS: Rats, weighing approximately 230 g, were divided into five groups. The control group was administered 0.5% carboxymethylcellulose orally once daily for 5 days. The second, third, fourth, and fifth groups were treated with 5-FU (50 mg/kg), 5-FU plus omeprazole (10 mg/kg), 5-FU plus lansoprazole (10 mg/kg), and 5-FU plus lafutidine (30 mg/kg) in the same way, respectively. The rats were sacrificed on the sixth day, and their stomachs and small intestines were removed. Using anti-mucin monoclonal antibodies, we compared the immunoreactivity in different areas of the rats' GI tracts as well as the mucin content. RESULTS: Body-weight decreased in rats in the 5-FU group. Lafutidine, but neither omeprazole nor lansoprazole, inhibited the 5-FU-induced weight loss. Mucosal damage and reduced mucin content in stomach and small intestine were observed in rats receiving 5-FU alone. In the stomach, all antisecretory drugs caused the protective effects against 5-FU-induced mucosal injury and alleviation of the decreased mucin accumulation. In the jejunum and ileum, lafutidine, but neither omeprazole nor lansoprazole, ameliorated the 5-FU-induced mucosal damage and decreased mucin accumulation. CONCLUSION: Lafutidine could offer the possibility of more effective prevention of CT-induced mucositis through the activation of GI mucus cells.



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Fwd: Raymark health issues remain a concern (Connecticut Post)



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From: Yahoo! News Search Results for asbestos cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Raymark health issues remain a concern (Connecticut Post)
To: mesothelioma77@gmail.com


STRATFORD — Local and state health officials Thursday tried to assure residents during a public workshop on Raymark waste at the Birdseye Municipal Complex that asbestos, lead and PCBs that

Fri, 18 Apr 2008 09:27:06 GMT

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Fwd: DDT and Breast Cancer: Cohn et al. Respond.



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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: DDT and Breast Cancer: Cohn et al. Respond.
To: mesothelioma77@gmail.com


[1]Environ Health Perspect. 2008 Apr; 116(4): A153-A154
Cohn BA, Cirillo PM, Sholtz RI, Wolff MS





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Fwd: Reply: Early onset breast cancer in black British women: a letter to the editor of British Journal of Cancer regarding early onset of breast cancer in a group of British black women.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Reply: Early onset breast cancer in black British women: a letter to the editor of British Journal of Cancer regarding early onset of breast cancer in a group of British black women.
To: mesothelioma77@gmail.com


[1]Br J Cancer. 2008 Apr 22; 98(8): 1483-4
Bowen R, Duffy S, Ryan D, Hart I, Jones L





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Source: http://www.hubmed.org/display.cgi?uids=18414475
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Fwd: Incorporating the amino acid properties to predict the significance of missense mutations.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Incorporating the amino acid properties to predict the significance of missense mutations.
To: mesothelioma77@gmail.com


[1]Amino Acids. 2008 Apr 16;
Lee TC, Lee AS, Li KB

Determining if missense mutations are deleterious is critical for the analysis of genes implicated in disease. However, the mutational effects of many missense mutations in databases like the Breast Cancer Information Core are unclassified. Several approaches have emerged recently to determine such mutational effects but none have utilized amino acid property indices. We modified a previously described phylogenetic approach by first classifying benign substitutions based on the assumption that missense mutations that are maintained in orthologs are unlikely to affect function. A consensus conservation score based on 16 amino acid properties was used to characterize the remaining substitutions. This approach was evaluated with experimentally verified T4 lysozyme missnese mutations and is shown to be able to sieve out putative biochemical and structurally important residues. The use of amino acid properties can enhance the prediction of biochemical and structurally important residues and thus also predict the significance of missense mutations.



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Source: http://www.hubmed.org/display.cgi?uids=18415037
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Fwd: Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.



---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:34 AM
Subject: Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.
To: mesothelioma77@gmail.com


[1]Scand J Gastroenterol. 2008; 43(5): 574-80
Ogura M, Hikiba Y, Maeda S, Matsumura M, Okano K, Sassa R, Yoshida H, Kawabe T, Omata M

OBJECTIVE: Although commonly practiced in Japan, the effectiveness of regular screening with upper gastrointestinal (UGI) endoscopy against gastric cancer has not been well evidenced. The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy. MATERIAL AND METHODS: The medical records of 833 patients with gastric ulcer (GU) and 2547 without ulcer (NU) were analyzed; these patients received long-term, repeated endoscopic examinations between 1969 and 2004. Gastric cancer incidence, death by gastric cancer, and overall survival were compared with those in a Japanese general population by calculating the standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs). RESULTS: The interval between UGI endoscopic examinations was 1.4 +/- 1.4 years in the GU group and 1.8 +/- 1.5 years in the NU group. During follow-up, 32 patients with GU and 61 in the NU group developed gastric cancer, showing annual incidence rates of 0.40% (95% CI: 0.24-0.56%) and 0.38% (0.28-0.48%), and SIRs of 2.21 (1.44-2.98) and 1.72 (1.29-2.15), respectively. The 5-year survival rate exceeded 80% among patients who developed gastric cancer. SMRs for gastric cancer and overall deaths were 0.50 (0.01-0.99) and 1.05 (0.87-1.23) in GU patients, and 0.45 (0.15-0.74) and 0.78 (0.69-0.88) in NU patients. There were no significant differences between the two groups in gastric cancer incidence, mortality from gastric cancer, and overall survival. CONCLUSIONS: Mortality from gastric cancer could be reduced by regular UGI endoscopy in a population with a high incidence of gastric cancer.



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Fwd: Jefferson County Public Schools sent out erroneous letters to students



 



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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:33 AM
Subject: Jefferson County Public Schools sent out erroneous letters to students
To: mesothelioma77@gmail.com


Story reported by Adrianna Hopkins The Jefferson County Public School System is backtracking, after sending hundreds of students a letter informing them their race would keep them out of Pleasure Ridge Park ...

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Fwd: Jefferson County Public Schools sent out erroneous letters to students



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 18, 2008 at 5:33 AM
Subject: Jefferson County Public Schools sent out erroneous letters to students
To: mesothelioma77@gmail.com


Story reported by Adrianna Hopkins The Jefferson County Public School System is backtracking, after sending hundreds of students a letter informing them their race would keep them out of Pleasure Ridge Park ...

Fri, 18 Apr 2008 01:55:50 GMT


Source: http://www.whas11.com/justposted/stories/041708whascwTopJCPS.7427330d.html
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