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Tuesday, June 17, 2008

Fwd: Lesbians and cancer: an overlooked health disparity.



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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, Jun 15, 2008 at 11:30 AM
Subject: Lesbians and cancer: an overlooked health disparity.
To: mesothelioma77@gmail.com


[1]Cancer Causes Control. 2008 Jun 13;
Brown JP, Tracy JK

OBJECTIVE: To evaluate the breast, cervical, ovarian, lung, and colorectal cancer literatures using a novel application of the cancer disparities grid to identify disparities along domains of the cancer continuum focusing on lesbians as a minority population. METHODS: Computerized databases were searched for articles published from 1981 to present. Cumulative search results identified 51 articles related to lesbians and disparities, which were classified by domain. RESULTS: The majority of articles identified were related to breast and cervical cancer screening. Barriers to adequate screening for both cancers include personal factors, poor patient-provider communication, and health care system factors. Tailored risk counseling has been successful in increasing lesbian's mammography and Pap screening. Ovarian, lung, and colorectal cancer have been virtually unexplored in this population. An "Adjustment to Illness/Quality of Life" domain was added to capture literature on psychosocial aspects of cancer. CONCLUSIONS: This review revealed a lack of research for specific cancers and for specific aspects of the cancer continuum. The limited number of studies identified focused on issues related to screening/prevention in cervical and breast cancers, with almost no attention to incidence, etiology, diagnosis, treatment, survival, morbidity, or mortality. We present implications for social and public health policy, research, and prevention.



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Source: http://www.hubmed.org/display.cgi?uids=18551371
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Fwd: Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, Jun 15, 2008 at 11:30 AM
Subject: Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity.
To: mesothelioma77@gmail.com


[1]Pharmacogenet Genomics. 2008 Jul; 18(7): 623-31
Fan L, Goh BC, Wong CI, Sukri N, Lim SE, Tan SH, Guo JY, Lim R, Yap HL, Khoo YM, Iau P, Lee HS, Lee SC

OBJECTIVES: Doxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly predictable. METHODS: We correlated CBR1 and CBR3 genotypes with the pharmacokinetics and pharmacodynamics of doxorubicin in 101 Southeast Asian breast cancer patients receiving first-line doxorubicin. RESULTS: A common CBR3 11G>A variant was associated with lower doxorubicinol area under the concentration-time curve (AUC)/doxorubicin AUC metabolite ratio (P=0.009, GG vs. AA; trend test, P=0.004), lower CBR3 expression in breast tumor tissue (P=0.001, GG vs. AA), greater tumor reduction (P=0.015, GG vs. AA), and greater percentage reduction of leukocyte and platelet counts at nadir (trend test, PA variant than Indians (PA was associated with higher doxorubicinol AUC (P=0.009, GG vs. AA) and CBR3 expression in breast tumor tissue (P=0.001, GG vs AA). CONCLUSION: Polymorphisms in CBR3 may explain interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.



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Source: http://www.hubmed.org/display.cgi?uids=18551042
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Fwd: Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, Jun 15, 2008 at 11:30 AM
Subject: Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.
To: mesothelioma77@gmail.com


[1]Carcinogenesis. 2008 Jun 10;
Brendle A, Lei H, Brandt A, Johansson R, Enquist K, Henriksson R, Hemminki K, Lenner P, Försti A

Integrins control the cell attachment to the extracellular matrix (ECM) and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions (UTRs). We examined the effect of single nucleotide polymorphisms (SNPs) in predicted miRNA taget sites of six integrin genes (ITGA3, ITGA6, ITGAv, ITGB3, ITGB4, ITGB5) on breast cancer (BC) risk and clinical outcome. Six SNPs were genotyped in 749 Swedish incident BC cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. We evaluated associations between genotypes and BC risk and clinical tumour characteristics. Survival probabilities were compared between different subgroups. As a novel finding several SNPs seemed to associate with the hormone receptor status. The strongest association was observed between the A allele of the SNP rs743554 in the ITGB4 gene and estrogen receptor negative (ER-) tumours (odds ratio [OR] 2.09, 95% confidence intervals [CIs] 1.19-3.67). The same SNP was associated with survival. The A allele carriers had a worse survival compared to the wild type genotype carriers (hazard ratio [HR] 2.11 95% CIs 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage. None of the SNPs was significantly associated with BC risk. As the ITGB4 SNP seems to influence tumour aggressiveness and survival, it may have prognostic value in the clinic.



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Source: http://www.hubmed.org/display.cgi?uids=18550570
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Fwd: Women Get Lung Cancer From Smoking at Same Rates as Men (MedicineNet.com)



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From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Women Get Lung Cancer From Smoking at Same Rates as Men (MedicineNet.com)
To: mesothelioma77@gmail.com


Title: Women Get Lung Cancer From Smoking at Same Rates as Men Category: Health News Created: 6/15/2008 2:00:00 AM Last Editorial Review: 6/16/2008

Mon, 16 Jun 2008 19:35:35 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=124fk3sul/*http%3A//www.medicinenet.com/guide.asp?s=rss&k=DailyHealth&a=90299
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Fwd: False-positive sentinel lymph nodes in breast cancer patients caused by benign glandular inclusions: report of three cases and review of the literature.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, Jun 15, 2008 at 11:30 AM
Subject: False-positive sentinel lymph nodes in breast cancer patients caused by benign glandular inclusions: report of three cases and review of the literature.
To: mesothelioma77@gmail.com


[1]Am J Clin Pathol. 2008 Jul; 130(1): 21-7
Peng Y, Ashfaq R, Ewing G, Leitch AM, Molberg KH

We report 3 cases of sentinel lymph nodes (SLNs) containing benign glandular inclusions (BGIs) in patients with breast carcinoma that were initially misdiagnosed as metastatic carcinoma.The first case had an SLN with glandular elements adjacent to a squamous inclusion cyst, the second had an SLN with a single complex gland showing apocrine features, and the third had 2 SLNs, each containing rare glands lined by bland columnar cells and surrounded by thin, fibrous bands. All glandular elements were distinctly different from the corresponding invasive carcinoma. Immunostains for myoepithelial markers revealed smooth muscle myosin reactivity and scattered p63+ nuclei, indicating the presence of myoepithelial cells. Based on morphologic and immunohistochemical findings, a diagnosis of BGIs was established.Our case series report indicates that comparison with the morphologic features of primary breast carcinoma and using immunohistochemical analysis for myoepithelial markers are important ancillary tools in distinguishing BGIs from metastatic carcinoma.



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Source: http://www.hubmed.org/display.cgi?uids=18550466
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Fwd: Healthwatch for June 16, 2008



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Healthwatch for June 16, 2008
To: mesothelioma77@gmail.com


Posted Monday, June 16, 2008 ; 01:06 PM Updated Monday, June 16, 2008 ; 05:45 PM The FDA says it found the source of a salmonella outbreak, strong evidence links traffic pollution to childhood allergies and ...

Tue, 17 Jun 2008 02:34:59 GMT


Source: http://www.wvnstv.com/story.cfm?func=viewstory&storyid=40077
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Fwd: Cancer-sniffing dogs



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Cancer-sniffing dogs
To: mesothelioma77@gmail.com


A South Korean firm said it has successfully cloned four dogs capable of sniffing out human cancers by using tissue from a retriever in Japan.

Tue, 17 Jun 2008 00:11:49 GMT


Source: http://www.dailytimes.com.pk/default.asp?page=2008\06\17\story_17-6-2008_pg9_9
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Fwd: Even revolutionaries have to moisturize



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Even revolutionaries have to moisturize
To: mesothelioma77@gmail.com


No other organ would stand for this kind of abuse. Men cut it, scrape it, sunburn it and generally abuse it every day.

Mon, 16 Jun 2008 23:02:22 GMT


Source: http://www.canada.com/saskatoonstarphoenix/story.html?id=84a48359-3f46-4581-99e1-38e4112a4544
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Fwd: Palace of Westminster Asbestos Problem Ignored



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Palace of Westminster Asbestos Problem Ignored
To: mesothelioma77@gmail.com


Clinica - the world's leading news service for the medical technology industry - has learned that staff and visitors to London's Houses of Parliament have been at risk of exposure to high levels of asbestos ...

Mon, 16 Jun 2008 20:00:29 GMT


Source: http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/06-16-2008/0004833087&EDATE=
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Fwd: Palace of Westminster Asbestos Problem Ignored



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Jun 16, 2008 at 10:45 PM
Subject: Palace of Westminster Asbestos Problem Ignored
To: mesothelioma77@gmail.com


Clinica - the world's leading news service for the medical technology industry - has learned that staff and visitors to London's Houses of Parliament have been at risk of exposure to high levels of asbestos ...

Mon, 16 Jun 2008 20:00:29 GMT


Source: http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/06-16-2008/0004833087&EDATE=
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Fwd: Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk.



---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, Jun 15, 2008 at 11:30 AM
Subject: Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk.
To: mesothelioma77@gmail.com


[1]Breast Cancer Res Treat. 2008 Jun 13;
Han J, Haiman C, Niu T, Guo Q, Cox DG, Willett WC, Hankinson SE, Hunter DJ

Purpose We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk. Methods In this nested case-control study of 239 prospectively ascertained premenopausal breast cancer cases and 477 matched controls within the Nurses' Health Study II, we evaluated 1,463 genetic variants in 60 candidate genes across five DNA repair pathways, along with DNA polymerases, Fanconi Anemia complementation groups, and other related genes. Results Four variants were associated with breast cancer risk with a significance level of

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Source: http://www.hubmed.org/display.cgi?uids=18551366
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