Fwd: Occupational wood dust exposure and the risk of laryngeal cancer: A population based case-control study in Germany.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Jul 16, 2008 at 9:21 AM
Subject: Occupational wood dust exposure and the risk of laryngeal cancer: A population based case-control study in Germany.
To: mesothelioma77@gmail.com


[1]Am J Ind Med. 2008 Jul 14;
Ramroth H, Dietz A, Ahrens W, Becher H

BACKGROUND: To investigate the effect of exposure to wood dust on the risk of laryngeal cancer. METHODS: A population-based case-control study on laryngeal cancer was conducted in South-West Germany between 1st of May 1998 to 31st of December 2000 with 257 histologically confirmed cases (236 males, 21 females), age 37 to 80 years, and 769 population controls (702 males, 67 females), 1:3 frequency matched by age and sex. Occupational exposures and other risk factors were obtained with face-to-face interviews using a detailed standardized questionnaire. The complete individual work history was assessed. Work conditions were obtained by job-specific questionnaires for selected jobs known to be associated with exposure to potential carcinogens. Additionally, a specific substance check-list was used as a method for exposure assessment. RESULTS: 43 (16.7%) cases (41 males, 2 females) and 107 (13.9%) controls (105 males, 2 females) reported wood dust exposure. Numbers were almost identical for two different methods of exposure assessment; however, the agreement of these methods was around 95%. A strong effect on laryngeal cancer risk after adjustment for smoking, alcohol and education was observed for high exposure to hardwood dust (OR = 2.6, 95% CI 1.3--5.2) and to softwood dust (OR = 2.2, 95% CI 1.1--4.2), as assessed by substance list. CONCLUSIONS: Our findings for higher exposure to hardwood and softwood dust contribute to the evidence that wood dust, in particular from hardwood is an independent risk factor. Am. J. Ind. Med. (c) 2008 Wiley-Liss, Inc.



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Source: http://www.hubmed.org/display.cgi?uids=18626911
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Fwd: Analysis of Clinical Applicability of the Breast Cancer Nomogram for Positive Sentinel Lymph Node: The Canadian Experience.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Mon, Jul 14, 2008 at 4:55 AM
Subject: Analysis of Clinical Applicability of the Breast Cancer Nomogram for Positive Sentinel Lymph Node: The Canadian Experience.
To: mesothelioma77@gmail.com


[1]Ann Surg Oncol. 2008 Jul 10;
Poirier E, Sideris L, Dubé P, Drolet P, Meterissian SH

BACKGROUND: A Breast Cancer Nomogram (BCN) for predicting nonsentinel lymph node (NSLN) involvement has been developed and prospectively tested in several series. However, its clinical applicability has never been tested among surgeons. METHODS: The BCN was applied to 209 SLN-positive patients. Its performance was assessed by the area under the receiver-operating characteristic (ROC) curve. Surgeons in Quebec were surveyed to determine the predicted NSLN positivity below which they would not dissect the axilla. The accuracy of the BCN was determined in this clinically relevant range. RESULTS: The predictive accuracy of the BCN had an area under the ROC curve of 0.687. Almost half of interviewed surgeons treat over 20 breast cancer per year. Fourteen out of 82 surgeons questioned would never leave the patient without a completion axillary dissection after a positive SLN, regardless of the BCN result. Seventy one percent of them would not complete axillary dissection if the prediction of a positive NSLN was

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Source: http://www.hubmed.org/display.cgi?uids=18618183
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Fwd: Morphologic Study of Nipple-Areola Complex in 600 Breasts.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Jul 16, 2008 at 9:21 AM
Subject: Morphologic Study of Nipple-Areola Complex in 600 Breasts.
To: mesothelioma77@gmail.com


[1]Aesthetic Plast Surg. 2008 Jul 15;
Sanuki JI, Fukuma E, Uchida Y

To investigate the morphologic characteristics of the nipple-areola complex, the diameter of the nipple-areola complex and the height of the nipple in 300 adult women (600 breasts) were measured using micrometer calipers. Furthermore, the morphologic characteristics were classified into four types by visual observation. Mean diameter of the areola was 4.0 cm, mean diameter of the nipple was 1.3 cm, and mean height of the nipple was 0.9 cm. From the morphologic point of view, the elevated plateau type without constriction (IIs) was most commonly found, being present in 60.2% of breasts. Inverted nipples (III) were found in 3.5% and unclassified type (IV) such as multiple or divided nipples was found in 0.3%. Because women have become sensitive about the appearance of their breasts and there is increasing cosmetic interest following surgery for breast carcinoma, operations on the nipple-areola complex are now common. When a surgeon counsels a patient and designs a reconstruction method prior to operation, these data may be helpful.



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Source: http://www.hubmed.org/display.cgi?uids=18626683
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Fwd: Development and evaluation of a problem-focused psychosocial intervention for patients with head and neck cancer.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Jul 16, 2008 at 9:21 AM
Subject: Development and evaluation of a problem-focused psychosocial intervention for patients with head and neck cancer.
To: mesothelioma77@gmail.com


[1]Support Care Cancer. 2008 Jul 15;
Semple CJ, Dunwoody L, Kernohan WG, McCaughan E

GOALS OF THE WORK: Patients with head and neck cancer have complex needs that affect many basic functions of life and contribute to substantial psychosocial problems. The aim of this study was to evaluate the effectiveness of a problem-focused intervention for patients with psychosocial dysfunction who had completed treatment for head and neck cancer. PATIENTS AND METHODS: Using a quasi-experimental design, 54 participants who were above pre-determined cutoff points for psychosocial dysfunction (hospital and depression scale, work and social adjustment scale) were given the opportunity to self-select into either the experimental group for the psychosocial intervention programme which was delivered in an individualised format, with bibliotherapy as an adjunct, or the control group for usual care. MAIN RESULTS: Analysis of covariance results demonstrated a reduction in psychological distress (anxiety, p = 0.001; depression, p = 0.005), improving social functioning (p = 0.048) and quality of life scores (p =

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Source: http://www.hubmed.org/display.cgi?uids=18626666
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Fwd: Noninvasive Cell Tracking.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Jul 16, 2008 at 9:21 AM
Subject: Noninvasive Cell Tracking.
To: mesothelioma77@gmail.com


[1]Handb Exp Pharmacol. 2008; 185/2: 305-321
Kiessling F

Cell-based therapies may gain future importance in defeating different kinds of diseases, including cancer, immunological disorders, neurodegenerative diseases, cardiac infarction and stroke. In this context, the noninvasive localization of the transplanted cells and the monitoring of their migration can facilitate basic research on the underlying mechanism and improve clinical translation.In this chapter, different ways to label and track cells in vivo are described. The oldest and only clinically established method is leukocyte scintigraphy, which enables a (semi)quantitative assessment of cell assemblies and, thus, the localization of inflammation foci. Noninvasive imaging of fewer or even single cells succeeds with MRI after labeling of the cells with (ultrasmall) superparamagentic iron oxide particles (SPIO and USPIO). However, in order to gain an acceptable signal-to-noise ratio, at a sufficiently high spatial resolution of the MR sequence to visualize a small amount of cells, experimental MR scanners working at high magnetic fields are usually required. Nevertheless, feasibility of clinical translation has been achieved by showing the localization of USPIO-labeled dendritic cells in cervical lymph nodes of patients by clinical MRI.Cell-tracking approaches using optical methods are important for preclinical research. Here, cells are labeled either with fluorescent dyes or quantum dots, or transfected with plasmids coding for fluorescent proteins such as green fluorescent protein (GFP) or red fluorescent protein (RFP). The advantage of the latter approach is that the label does not get lost during cell division and, thus, makes imaging of proliferating transplanted cells (e.g., tumor cells) possible.In summary, there are several promising options for noninvasive cell tracking, which have different strengths and limitations that should be considered when planning cell-tracking experiments.



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Source: http://www.hubmed.org/display.cgi?uids=18626608
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