---------- Forwarded message ----------
From:
HubMed - breast cancer <
rssfwd@rssfwd.com>
Date: Sat, May 3, 2008 at 11:09 PM
Subject: Increased expression of osteopontin in patients with triple-negative breast cancer.
To:
mesothelioma77@gmail.com[1]Eur J Clin Invest. 2008 Apr 30;
Wang X, Chao L, Ma G, Chen L, Tian B, Zang Y, Sun J
Background Patients with triple-negative [oestrogen receptor (ER) negative, progesterone receptor (PR) negative, and human epidermal growth factor receptor 2 (HER-2/neu) negative] breast cancer, accounting for about 15% of breast cancer cases, are associated with aggressive histology, poor prognosis and shorter survival. Osteopontin is a chemokine-like phosphorylated glycoprotein that plays important role in cancer progression and is found to be a metastasis-associated protein in breast cancer. The goal of the study was to evaluate osteopontin protein expression levels in triple-negative breast carcinomas to determine if they correlated with clinicopathological parameters, thus providing additional support for osteopontin functioning and better understanding of triple-negative breast cancer. Materials and methods A database of 239 patients, in whom all three markers (ER, PR, and HER-2/neu) were available, was reviewed. We performed osteopontin protein expression analyses by means of immunohistochemistry on 117 breast carcinoma tissue samples, and then assessed the mean value of osteopontin expression against triple-negative status and clinicopathological parameters. Results Of the 239 patients in the study, 47 were classified as triple negative. Of the 117 osteopontin-test patients in this cohort, mean osteopontin levels were significantly higher in the triple-negative breast cancers than in non-triple-negative subtype (P = 0.035). TNM (tumours, nodes, metastases) stage were significantly associated with osteopontin levels (P = 0.038). Univariate analysis showed tumour cell osteopontin positivity above an optimized cut-point to be significantly associated with decreased disease-free survival, but not overall survival. In the multivariate model, osteopontin was an independent prognostic factor for disease-free survival. Conclusions Patients with osteopontin overexpression develop predominantly triple-negative tumours. Osteopontin overexpression is associated with tumour aggressiveness and poor prognosis.
___
Source:
http://www.hubmed.org/display.cgi?uids=18452545--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Your Finance:
Sitemap
Debts, Loans And Consolidation Tips, Guide, Strategies And Info:
Debts and Loan Consolidation
Managing Your Debts
Debt Consolidation Loan
Consolidate Debt Loans: For Better Debt Management
Consolidate Debt Loans: To Eliminate Credit Card Debts
Consolidate Debt Loans
Consolidate Debt Loans For Your School Debts
Debt Consolidation UK
Debt Consolidation UK; Secured and Unsecured Debt Consolidation Explained
Private Student Loans: A Parent's Best Choice?
College Consolidation Loans
School Consolidation Loan Guide
School Loan Consolidation
School Loan Consolidation: Your Much Needed Information
School Consolidation Loan
Enter Bankruptcy Protection
Bankruptcy Mailing List
Bankruptcy Marketing
Your Mortgage Tips, Guide, Strategies And Info
Mortgage Loans
Mortgage Refinancing
How Much Mortgage Can I Afford?
Best Mortgage Rates Refinancing
Low Mortgage Rate Refinance
Connecticut Mortgage Refinancing
Mortgage Loan Refinancing In Britain
UK Mortgage Payment Calculator
Arkansas Refinance Mortgage Rates
Home Loan Rates Berkeley Springs
Home Loan Rates WV
Mortgage Rate History
What is Subprime Mortgage?
Foreclosures Tips, Guide, Strategies and Info Sites
Foreclosures
Foreclosures Bank Owned
Mortgage Foreclosure Appraisal
Property Foreclosures
Reasons Foreclosures Occur
Avoid Foreclosure
Deed In Lieu Of Foreclosure
Regulations Preventing Foreclosure
Your Real Estate Tips, Guide, Strategies And Info:
Real Estate: Important Things to Remember
MS Beach Vacation Condos
Real Estate Marbella
Franklin TN Real Estate
Hud Homes Savannah Georgia
Margate Real Estate
Hud Approved Builders
It's All About Your Insurance
Insurance Premiums and Your DUI, DWI
The Role of Insurance
Insurance Defined
Low Car Insurance Rate Canada
Your DWI And DUI Tips, Guide And Info:
97402 Dui Classses
Austin DWI Attorney Info
Florida DWI Arrest
Austin DWI and DUI Defined
Florida Dwi Defense
Your Pet Dogs Needs, Tips, Guide, Strategies, and Info
Pet Dogs Wellness
Air Filled Dog Bed
Transport Dog Crates
Dog Transport
Air Filled Dog Bed: Your Best Friends Comfort
Unique Dog Collars
Dog Crate Training
Popular Transport Dog Crates
Puppy Colic
Pet Dogs: Breeds With Behavioral Problems?
Your Health Tips, Guide and Info
Health Wellness
Relieve Stress Anxiety Tensions
Holiday Stress
Mind Body Yoga
Mesothelioma
Mesothelioma diagnosis: What You Need To Know
Daily Recommended Relaxation
Transcendental Meditation
More Articles For You
Related Articles