Fwd: Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Feb 22, 2008 at 10:17 AM
Subject: Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers.
To: mesothelioma77@gmail.com


[1]World J Gastroenterol. 2008 Feb 21; 14(7): 1053-9
Buisine MP, Wacrenier A, Mariette C, Leteurtre E, Escande F, Aissi S, Ketele A, Leclercq A, Porchet N, Lesuffleur T

AIM: To investigate the polymorphic simple sequence repeat in intron 1 of the epidermal growth factor receptor gene (EGFR) (CA-SSR I), which is known to affect the efficiency of gene transcription as a putative target of the mismatch repair (MMR) machinery in colorectal tumors. METHODS: The CA-SSR I genotype was analyzed in a total of 86 primary colorectal tumors, selected upon their microsatellite instability (MSI) status [42 with high frequency MSI (MSI-H) and 44 microsatellite stable (MSS)] and their respective normal tissue. The effect of the CA-SSR I genotype on the expression of the EGFR gene was evaluated in 18 specimens using quantitative real-time reverse transcription PCR and immunohistochemistry. RESULTS: Mutations in CA-SSR I were detected in 86% (36 of 42) of MSI-H colorectal tumors and 0% (0 of 44) of MSS tumors, indicating the EGFR gene as a novel putative specific target of the defective MMR system (P

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Fwd: Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Fri, Feb 22, 2008 at 10:17 AM
Subject: Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.
To: mesothelioma77@gmail.com

[1]Cancer. 2008 Feb 19;
Wang Y, Zhang D, Zheng W, Luo J, Bai Y, Lu Z

BACKGROUND: Aberrant DNA methylation of the CpG islands for cancer-related genes is among the earliest and most frequent alterations in cancer and may be useful for diagnosing cancer or evaluating recurrent disease. METHODS: In this study, a 3-dimensional (3-D), polyacrylamide gel-based DNA microarray coupled with linker-polymerase chain reaction (PCR) was developed to detect hypermethylation of CpG islands in multiple genes from a large group of different samples. The authors determined the frequency of aberrant promoter methylation of 15 genes in 28 resected primary nonsmall cell lung cancers (NSCLCs) and in 12 corresponding nonmalignant lung tissues. RESULTS: Methylation frequencies in the tumor samples were detected in 18% of samples for the breast cancer 1 gene BRCA1, in 43% of samples for the tissue inhibitor of metalloproteinase 3 gene TIMP-3, in 38% of samples for the cyclin-dependent kinase inhibitor 4A gene p16INK4a, in 54% of samples for the cadherin 13 gene CDH13, in 50% of samples for the death-associated protein kinase gene DAPK, in 11% of samples for the E-cadherin gene ECAD, in 25% of samples for the insulin-like growth factor binding protein 7 gene IGFBP7, in 18% of samples for the Ras association domain family 1 gene RASSF1, in 68% of samples for the adenomatous polyposis coli gene APC, in 7% of samples for the cyclin-dependent kinase inhibitor gene p15, in 18% of samples for the CD44 cell adhesion molecule gene, in 29% of samples for the human Mut-L homolog gene hMLH, in 32% of samples for the human telomerase reverse transcriptase gene hTERT, in 64% of samples for the calcitonin gene-related polypeptide alpha gene CALCA, and in 54% of samples for the estrogen receptor gene ER; however, methylation was not observed in the majority of corresponding nonmalignant tissues. Six samples in from 28 tumors had >6 genes methylated, and 1 sample had 13 genes methylated. Methylation of these genes was correlated with some clinicopathologic patient characteristics. CONCLUSIONS: This study demonstrated that a 3-D microarray could be used to detect DNA hypermethylation and provided a high-throughput platform for DNA hypermethylation analysis. Cancer 2008. (c) 2008 American Cancer Society.



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Fwd: [Systemic treatment of non-small cell lung cancer - recommendations based on the results of reliable clinical trials.]

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From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Fri, Feb 22, 2008 at 10:18 AM
Subject: [Systemic treatment of non-small cell lung cancer - recommendations based on the results of reliable clinical trials.]
To: mesothelioma77@gmail.com


[1]Pneumonol Alergol Pol. 2008; 76(1): 44-52
Jassem J, Drosik K, Dziadziuszko R, Kordek R, Kozielski J, Kowalski D, Krzakowski M, Nikliński J, Olszewski W, Orłowski T, Ramlau R, Roszkowski-Śliż K

Lung cancer is in Poland the most common malignancy. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung tumors. In the multidisciplinary treatment of non-small cell lung cancer patients the role of chemotherapy and, most recently, molecular targeted therapy is increasing. In 2005 we published recommendations for systemic treatment of non-small cell lung cancer and mesothelioma. As many new studies have been published since, it was necessary to update this document. We present here a consensus statement on this topic, prepared by a panel of experts in oncology, thoracic surgery, pathology and pneumonology.



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Mesothelioma Cancer   

Unlike lung cancer, there is no association between mesothelioma and smoking Mesothelioma is a wizardry of cancer that is almost always caused by previous exposure to asbestos Mesothelioma is the word used to describe a cancerous tumor that involves the mesothelial cells of an organ, often the lungs, heart, or abdominal organs. Its greatest easily understood site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

 Surpassingly people who develop mesothelioma get hold of worked on jobs where they inhaled asbestos particles, or carry been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products. It can also occur in children; however, these cases are not thought to be associated with asbestos exposure.

 Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity).  A history of exposure to asbestos may increase clinical suspicion for mesothelioma. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. This is the end of a expertise that usually begins with symptoms that send most people to the doctor: a fluid build-up around the lungs (pleural effusions), shortness of breath, suffering in the chest, or suffering or swelling in the abdomen.

 A physical examination is performed, followed by chest X-ray and often lung function tests. Shortness of breath, cough, and aches and in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

 If the cancer has body beyond the mesothelium to other parts of the spread, symptoms may include aches and, trouble swallowing, or swelling of the neck or make contact with.

Tissue is removed, placed under the microscope, and a pathologist makes a definitive diagnosis, and issues a pathology report. Malignant mesothelioma is a rare type of cancer in which malignant cells are found in the sac lining the chest or abdomen. Extremely malignant mesotheliomas accept complex karyotypes, with extensive aneuploidy and rearrangement of swarms chromosomes. 

 

Most people with malignant mesothelioma require worked on jobs where they breathed asbestos. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.

 Malignant mesothelioma has a peak incidence 35-45 years after asbestos exposure. Malignant mesothelioma has also been linked to remedial radiation using thorium dioxide and zeolite, a silicate in the soil.

 Malignant mesothelioma is often just called simply Mesothelioma and is a form of lung cancer that is quite rare.

 

Malignant mesothelioma is more explicit in men, with a male-to-female ratio of 3:1. In this disease, malignant cells develop in the mesothelium, a protective lining that covers extremely of the body's internal organs.

 

The be obliged of radiation therapy in pleural mesothelioma has been shown to alleviate aches and in the majority of patients that are treated. But unfortunately, the duration of symptom control is short-lived. Radiation has no effect on survival, but it has caused significant palliation in 50% of patients treated for chest aches and and chest wall metastasis. There are now a number of cancer treatment options open to mesothelioma victims. Extrapleural pneumonectomy for selected victims with very early stage disease may extend recurrence-free survival, but the impact it has on overall survival is unknownat this time.

 

Surgical resection has been relied upon because radiation and chemotherapy set up been ineffective legitimate treatments. The 2 surgical procedures used are pleurectomy with decortication and extrapleural pneumonectomy.

 

www.lingwellness.com

 

Fwd: The people's councillor dies

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From: Live Search News: asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 12:15 AM
Subject: The people's councillor dies
To: mesothelioma77@gmail.com


Vancouver Sun - Former District of North Vancouver councillor Ernie Crist died on Saturday. He was 79 and had been fighting lung cancer, likely caused by breathing asbestos at the North Vancouver shipyards where he worked for many years. His passing was noted at ...

Wed, 20 Feb 2008 18:54:00 GMT

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Fwd: Deciphering hormone therapy: Conventional vs. compounded

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 12:15 AM
Subject: Deciphering hormone therapy: Conventional vs. compounded
To: mesothelioma77@gmail.com

Q : I've been reading a lot about bioidentical hormones lately. What are they exactly? Are they an improvement on the usual hormone-replacement therapy? A : Bioidentical hormones are chemically identical to ...

Thu, 21 Feb 2008 01:47:19 GMT

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Source: http://www.chicagotribune.com/features/lifestyle/q/chi-0224_doc_r_k_dfeb24,1,6053690.story
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Fwd: Legendary N. Van politician dies

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 12:15 AM
Subject: Legendary N. Van politician dies
To: mesothelioma77@gmail.com

Longtime North Vancouver councillor Ernie Crist was recently honoured with the District of North Vancouvers highest hounour, Freedom of the District.

Thu, 21 Feb 2008 01:43:41 GMT

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Source: http://www.bclocalnews.com/greater_vancouver/northshoreoutlook/news/15812952.html
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Fwd: HIV/AIDS in Black America: What You Don't Know Can Kill You

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 12:15 AM
Subject: HIV/AIDS in Black America: What You Don't Know Can Kill You
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In March 1981, doctors and pharmacists began discovering a medical phenomenon. Eight young New Yorkers had developed red and purple lesions, which doctors would diagnose as an aggressive form of Kaposi's ...

Thu, 21 Feb 2008 01:56:40 GMT

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Source: http://www.seattlemedium.com/news/Article/Article.asp?sID=3&NewsID=86200
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Fwd: Report: Big Tobacco's Guinea Pigs-How an Unregulated Industry...

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 12:15 AM
Subject: Report: Big Tobacco's Guinea Pigs-How an Unregulated Industry...
To: mesothelioma77@gmail.com

Report: Big Tobacco's Guinea Pigs-How an Unregulated Industry Experiments on America's Kids and Consumers Press release: "An insidious new generation of tobacco products is threatening efforts to reduce tobacco ...

Thu, 21 Feb 2008 02:28:36 GMT

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Source: http://www.bespacific.com/mt/archives/017565.html
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