From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Fri, Feb 22, 2008 at 10:18 AM
Subject: [Systemic treatment of non-small cell lung cancer - recommendations based on the results of reliable clinical trials.]
To: mesothelioma77@gmail.com
[1]Pneumonol Alergol Pol. 2008; 76(1): 44-52
Jassem J, Drosik K, Dziadziuszko R, Kordek R, Kozielski J, Kowalski D, Krzakowski M, Nikliński J, Olszewski W, Orłowski T, Ramlau R, Roszkowski-Śliż K
Lung cancer is in Poland the most common malignancy. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung tumors. In the multidisciplinary treatment of non-small cell lung cancer patients the role of chemotherapy and, most recently, molecular targeted therapy is increasing. In 2005 we published recommendations for systemic treatment of non-small cell lung cancer and mesothelioma. As many new studies have been published since, it was necessary to update this document. We present here a consensus statement on this topic, prepared by a panel of experts in oncology, thoracic surgery, pathology and pneumonology.
___
Source: http://www.hubmed.org/display.cgi?uids=18283654
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
=========================================================================================
Mesothelioma Cancer
Unlike lung cancer, there is no association between mesothelioma and smoking Mesothelioma is a wizardry of cancer that is almost always caused by previous exposure to asbestos Mesothelioma is the word used to describe a cancerous tumor that involves the mesothelial cells of an organ, often the lungs, heart, or abdominal organs. Its greatest easily understood site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).
Surpassingly people who develop mesothelioma get hold of worked on jobs where they inhaled asbestos particles, or carry been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products. It can also occur in children; however, these cases are not thought to be associated with asbestos exposure.
Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). A history of exposure to asbestos may increase clinical suspicion for mesothelioma. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. This is the end of a expertise that usually begins with symptoms that send most people to the doctor: a fluid build-up around the lungs (pleural effusions), shortness of breath, suffering in the chest, or suffering or swelling in the abdomen.
A physical examination is performed, followed by chest X-ray and often lung function tests. Shortness of breath, cough, and aches and in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.
If the cancer has body beyond the mesothelium to other parts of the spread, symptoms may include aches and, trouble swallowing, or swelling of the neck or make contact with.
Tissue is removed, placed under the microscope, and a pathologist makes a definitive diagnosis, and issues a pathology report. Malignant mesothelioma is a rare type of cancer in which malignant cells are found in the sac lining the chest or abdomen. Extremely malignant mesotheliomas accept complex karyotypes, with extensive aneuploidy and rearrangement of swarms chromosomes.
Most people with malignant mesothelioma require worked on jobs where they breathed asbestos. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.
Malignant mesothelioma has a peak incidence 35-45 years after asbestos exposure. Malignant mesothelioma has also been linked to remedial radiation using thorium dioxide and zeolite, a silicate in the soil.
Malignant mesothelioma is often just called simply Mesothelioma and is a form of lung cancer that is quite rare.
Malignant mesothelioma is more explicit in men, with a male-to-female ratio of 3:1. In this disease, malignant cells develop in the mesothelium, a protective lining that covers extremely of the body's internal organs.
The be obliged of radiation therapy in pleural mesothelioma has been shown to alleviate aches and in the majority of patients that are treated. But unfortunately, the duration of symptom control is short-lived. Radiation has no effect on survival, but it has caused significant palliation in 50% of patients treated for chest aches and and chest wall metastasis. There are now a number of cancer treatment options open to mesothelioma victims. Extrapleural pneumonectomy for selected victims with very early stage disease may extend recurrence-free survival, but the impact it has on overall survival is unknownat this time.
Surgical resection has been relied upon because radiation and chemotherapy set up been ineffective legitimate treatments. The 2 surgical procedures used are pleurectomy with decortication and extrapleural pneumonectomy.