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Fwd: Paclitaxel plus Bevacizumab for Metastatic Breast Cancer.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Apr 12, 2008 at 8:54 PM
Subject: Paclitaxel plus Bevacizumab for Metastatic Breast Cancer.
To: mesothelioma77@gmail.com

[1]N Engl J Med. 2008 Apr 10; 358(15): 1637-1638
Haines IE, Miklos GL, Rossi A, Torri V, Gridelli C, Miller KD, Wang M, Davidson NE

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Source: http://www.hubmed.org/display.cgi?uids=18403775
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Fwd: Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Apr 12, 2008 at 8:54 PM
Subject: Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk.
To: mesothelioma77@gmail.com

[1]J Epidemiol. 2008 Mar; 18(2): 77-83
Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A,

BACKGROUND: Evidence is lacking regarding the relationship between cigarette smoking and breast cancer in Japanese women. We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. METHODS: Our study comprised 34,401 women aged 40-79 years who had not been diagnosed previously with breast cancer and who provided information on smoking status at baseline (1988-1990). The subjects were followed from enrollment until December 31, 2001. Cox proportional-hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between breast cancer incidence and tobacco smoke. RESULTS: During 271,412 person-years of follow-up, we identified 208 incident cases of breast cancer. Active smoking did not increase the risk of breast cancer, with a HR for current smokers of 0.67 (95% CI: 0.32-1.38). Furthermore, an increased risk of breast cancer was not observed in current smokers who smoked a greater number of cigarettes each day. Overall, passive smoking at home or in public spaces was also not associated with an increased risk of breast cancer among nonsmokers. Women who reported passive smoking during childhood had a statistically insignificant increase in risk (HR: 1.24; 95% CI: 0.84-1.85), compared with those who had not been exposed during this time. CONCLUSION: Smoking may not be associated with an increased risk of breast cancer in this cohort of Japanese women.

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Source: http://www.hubmed.org/display.cgi?uids=18403857
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Fwd: Risk factors and adjuvant chemotherapy in the treatment of endometrial cancer.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Apr 12, 2008 at 8:54 PM
Subject: Risk factors and adjuvant chemotherapy in the treatment of endometrial cancer.
To: mesothelioma77@gmail.com

[1]J BUON. 2008 Jan-Mar; 13(1): 23-30
Stanojevic Z, Djordjevic B, Todorovska I, Lilic V, Zivadinovic R, Dunjic O

Endometrial carcinoma is the most common and potentially curable gynecologic malignant neoplasm. The staging of endometrial cancer, according to the International Federation of Gynecology and Obstetrics (FIGO), is surgical. Recent studies suggest a therapeutic benefit associated with extensive retroperitoneal lymph node evaluation to determine the disease extent and thereby more effectively direct potentially life-saving adjuvant therapy. Due to the increasing number of endometrial cancer patients who undergo surgical staging, some independent prognostic factors have been identified in early stages (stage I-II), including lymph-vascular space involvement, histologic grade 3, aggressive histologic subtypes (uterine papillary serous carcinoma, clear cell carcinoma), depth of myometrial invasion, cervical invasion and the age of patients. Adjuvant radiation therapy, known to offer survival benefit in advanced- stage disease, may also offer survival benefit in intermediate- risk surgical stage I, but this is followed by a significant risk of serious complications. Based on randomized clinical trials, this review identified that only a limited body of evidence is available which can help clinicians make decisions about adjuvant chemotherapy of patients with highrisk stage I and II, as well as stage IIIA endometrial cancer. Further investigations are required to define the subgroup of patients who benefit from postoperative adjuvant chemotherapy. In addition, the optimal regimen remains to be defined as all of them (doxorubicin/cisplatin - AP, cyclophosphamide/ doxorubicin/cisplatin - CAP, paclitaxel/carboplatin - TC, paclitaxel/doxorubicin/cisplatin - TAP) cause significant toxicity. Thereby, combination of carboplatin plus paclitaxel represents an efficacious, low-toxicity regimen for managing intermediate-risk surgical stage I, as well as advanced or recurrent endometrial cancer.

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Source: http://www.hubmed.org/display.cgi?uids=18404782
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Fwd: Optimistic about lungs

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Apr 12, 2008 at 8:54 PM
Subject: Optimistic about lungs
To: mesothelioma77@gmail.com

Nihilistic no more about lung cancer - treating the lung cancer patient optimally and effectively WE approached the patient with advanced lung cancer nihilistically until about 10 years ago.

Sun, 13 Apr 2008 00:18:42 GMT

Source: http://thestar.com.my/health/story.asp?file=/2008/4/13/health/20906233&sec=health
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