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Tuesday, March 25, 2008
Fwd: Economic evaluation and health-related quality of life.
---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Economic evaluation and health-related quality of life.
To: mesothelioma77@gmail.com
[1]Pediatr Blood Cancer. 2008 Mar 21; 50(S5): 1112-1115
Calaminus G, Barr R
Health-related quality of life (HRQL) is concerned with the opportunities that a person's health status affords, the constraints that it places upon the person and the value that a person places on his or her health status. The rationale for measuring HRQL falls into three categories: discrimination, evaluation, and prediction. Measures have to meet generally accepted psychometric criteria such as acceptability, reliability/reproducibility, responsiveness, validity, interpretability, and usefulness. HRQL instruments have been designed for self-administration or administration by interviews and some have been adapted to multiple cultural/linguistic needs. For adolescents and young adults with cancer several instruments are available. Overall HRQL is compromised, to varying degrees, in such survivors by comparison with peers in the general population; and the burden of morbidity is greatest after brain and bone tumors. As there is a burden of treatment-related morbidity and as the number of survivors within the health care system is growing, the economic dimension of care and cure has to be taken into consideration. Economic evaluation affords a comparison of the costs and consequences (effects) of relevant therapeutic alternatives. The future research activities with respect to HRQL have to consider these new dimensions of care. Pediatr Blood Cancer 2008:50:1112-1115. (c) 2008 Wiley-Liss, Inc.
___
Source: http://www.hubmed.org/display.cgi?uids=18360834
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Economic evaluation and health-related quality of life.
To: mesothelioma77@gmail.com
[1]Pediatr Blood Cancer. 2008 Mar 21; 50(S5): 1112-1115
Calaminus G, Barr R
Health-related quality of life (HRQL) is concerned with the opportunities that a person's health status affords, the constraints that it places upon the person and the value that a person places on his or her health status. The rationale for measuring HRQL falls into three categories: discrimination, evaluation, and prediction. Measures have to meet generally accepted psychometric criteria such as acceptability, reliability/reproducibility, responsiveness, validity, interpretability, and usefulness. HRQL instruments have been designed for self-administration or administration by interviews and some have been adapted to multiple cultural/linguistic needs. For adolescents and young adults with cancer several instruments are available. Overall HRQL is compromised, to varying degrees, in such survivors by comparison with peers in the general population; and the burden of morbidity is greatest after brain and bone tumors. As there is a burden of treatment-related morbidity and as the number of survivors within the health care system is growing, the economic dimension of care and cure has to be taken into consideration. Economic evaluation affords a comparison of the costs and consequences (effects) of relevant therapeutic alternatives. The future research activities with respect to HRQL have to consider these new dimensions of care. Pediatr Blood Cancer 2008:50:1112-1115. (c) 2008 Wiley-Liss, Inc.
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Source: http://www.hubmed.org/display.cgi?uids=18360834
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Fwd: Nipple-sparing mastectomy: risk of nipple-areolar recurrences in a series of 579 cases.
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Nipple-sparing mastectomy: risk of nipple-areolar recurrences in a series of 579 cases.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res Treat. 2008 Mar 22;
Petit JY, Veronesi U, Rey P, Rotmensz N, Botteri E, Rietjens M, Garusi C, De Lorenzi F, Martella S, Bosco R, Manconi A, Luini A, Galimberti V, Veronesi P, Ivaldi GB, Orecchia R
Background When the conservative treatment is not recommended, Nipple Sparing Mastectomy (NSM) is proposed more and more frequently for the surgical treatment of breast cancer. The risk of local recurrence behind the nipple areolar complex (NAC) is the main limiting factor of the NSM procedure. To minimize such risk, we proposed in 2002 a intraoperative radiotherapy of the preserved NAC. Patients and methods From March 2002 to November 2006, 579 cases (in 570 patients) of NSM were performed for carcinoma. The median follow up time was 19 months (Range: 1-60). The subcutaneous mastectomy was performed through an incision removing a portion of the skin overlying the tumour. An extemporaneous histological examination was performed on the retroareolar glandular tissue. If the histology was positive the patient was not considered eligible. Then an intraoperative radiotherapy with electrons (ELIOT) of 16 Gy in one shot was delivered on the NAC area. An immediate breast reconstruction was done using implants in most cases and in several cases a musculocutaneous flaps, usually in large breast. The number of local recurrences was recorded and the correlation between their occurrence and the clinical and histological criteria were analysed using the Gray test statistical method in a competing framework. Results In 516 cases the negative retroareolar frozen section biopsy was confirmed by the final histology, while in 63 cases, the final histology showed foci of carcinoma. Seven out of these 63 cases underwent a secondary NAC removal. In the 56 cases which preserved areolas we did not observe any local recurrence after 19 months follow up. The probability of retro areola positive histology increases with the tumour size. and was not related to the nodal status. The rate of local relapses was 0.9% per year. We didn't find any significant difference in the local relapse rate according to different patient's and tumour's features. Most relapses were located close to the tumour bed but never in the NAC area. Conclusion Our study confirms that the local recurrence rate in the NSM completed with local radiotherapy on the NAC is not higher than the usual rate observed in the literature and the preservation of the NAC does not increase the risk. The absence of local recurrence in the region where a portion of glandular tissue has been purposely preserved is a good argument in favour of ELIOT.
___
Source: http://www.hubmed.org/display.cgi?uids=18360773
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Nipple-sparing mastectomy: risk of nipple-areolar recurrences in a series of 579 cases.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res Treat. 2008 Mar 22;
Petit JY, Veronesi U, Rey P, Rotmensz N, Botteri E, Rietjens M, Garusi C, De Lorenzi F, Martella S, Bosco R, Manconi A, Luini A, Galimberti V, Veronesi P, Ivaldi GB, Orecchia R
Background When the conservative treatment is not recommended, Nipple Sparing Mastectomy (NSM) is proposed more and more frequently for the surgical treatment of breast cancer. The risk of local recurrence behind the nipple areolar complex (NAC) is the main limiting factor of the NSM procedure. To minimize such risk, we proposed in 2002 a intraoperative radiotherapy of the preserved NAC. Patients and methods From March 2002 to November 2006, 579 cases (in 570 patients) of NSM were performed for carcinoma. The median follow up time was 19 months (Range: 1-60). The subcutaneous mastectomy was performed through an incision removing a portion of the skin overlying the tumour. An extemporaneous histological examination was performed on the retroareolar glandular tissue. If the histology was positive the patient was not considered eligible. Then an intraoperative radiotherapy with electrons (ELIOT) of 16 Gy in one shot was delivered on the NAC area. An immediate breast reconstruction was done using implants in most cases and in several cases a musculocutaneous flaps, usually in large breast. The number of local recurrences was recorded and the correlation between their occurrence and the clinical and histological criteria were analysed using the Gray test statistical method in a competing framework. Results In 516 cases the negative retroareolar frozen section biopsy was confirmed by the final histology, while in 63 cases, the final histology showed foci of carcinoma. Seven out of these 63 cases underwent a secondary NAC removal. In the 56 cases which preserved areolas we did not observe any local recurrence after 19 months follow up. The probability of retro areola positive histology increases with the tumour size. and was not related to the nodal status. The rate of local relapses was 0.9% per year. We didn't find any significant difference in the local relapse rate according to different patient's and tumour's features. Most relapses were located close to the tumour bed but never in the NAC area. Conclusion Our study confirms that the local recurrence rate in the NSM completed with local radiotherapy on the NAC is not higher than the usual rate observed in the literature and the preservation of the NAC does not increase the risk. The absence of local recurrence in the region where a portion of glandular tissue has been purposely preserved is a good argument in favour of ELIOT.
___
Source: http://www.hubmed.org/display.cgi?uids=18360773
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Fwd: Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast: a cohort study.
---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast: a cohort study.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res Treat. 2008 Mar 22;
Cui Y, Page DL, Lane DS, Rohan TE
Menstrual and reproductive history and postmenopausal hormone use are well-established risk factors for breast cancer. However, previous studies that have assessed these factors in association with risk of benign proliferative epithelial disorders (BPED) of the breast, putative precursors of breast cancer, have yielded inconsistent findings. To investigate these associations, we conducted a cohort study among 68,132 postmenopausal women enrolled in the Women's Health Initiative randomized clinical trials. Women were prospectively followed and those reporting an open surgical biopsy or a core needle biopsy had histological sections obtained for centralized pathology review. Over an average of 7.8 years of follow-up, we identified 1,792 women with BPED of the breast. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence limits (CLs) for the associations of interest. Menstrual and reproductive histories were not associated with risk of BPED of the breast, overall or by histological subtype. Women who had used postmenopausal hormones for 15 years or more had a two-fold increase in risk of BPED of the breast compared to women who had never used postmenopausal hormones (HR = 2.03 95% CL = 1.73, 2.38) and the increase in risk was observed for both BPED of the breast without atypia and for atypical hyperplasia. Furthermore, the risk of BPED of the breast decreased with time since cessation of use so that there was essentially no increase in risk 5 or more years after ending use (HR for stopping >/=5 years earlier = 0.96, 95%CL = 0.79, 1.16; HR for stopping
___
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:50 PM
Subject: Menstrual and reproductive history, postmenopausal hormone use, and risk of benign proliferative epithelial disorders of the breast: a cohort study.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res Treat. 2008 Mar 22;
Cui Y, Page DL, Lane DS, Rohan TE
Menstrual and reproductive history and postmenopausal hormone use are well-established risk factors for breast cancer. However, previous studies that have assessed these factors in association with risk of benign proliferative epithelial disorders (BPED) of the breast, putative precursors of breast cancer, have yielded inconsistent findings. To investigate these associations, we conducted a cohort study among 68,132 postmenopausal women enrolled in the Women's Health Initiative randomized clinical trials. Women were prospectively followed and those reporting an open surgical biopsy or a core needle biopsy had histological sections obtained for centralized pathology review. Over an average of 7.8 years of follow-up, we identified 1,792 women with BPED of the breast. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence limits (CLs) for the associations of interest. Menstrual and reproductive histories were not associated with risk of BPED of the breast, overall or by histological subtype. Women who had used postmenopausal hormones for 15 years or more had a two-fold increase in risk of BPED of the breast compared to women who had never used postmenopausal hormones (HR = 2.03 95% CL = 1.73, 2.38) and the increase in risk was observed for both BPED of the breast without atypia and for atypical hyperplasia. Furthermore, the risk of BPED of the breast decreased with time since cessation of use so that there was essentially no increase in risk 5 or more years after ending use (HR for stopping >/=5 years earlier = 0.96, 95%CL = 0.79, 1.16; HR for stopping
___
Source: http://www.hubmed.org/display.cgi?uids=18360772
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Fwd: Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer.
---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer.
To: mesothelioma77@gmail.com
[1]Int J Cancer. 2008 Mar 21;
Beebe-Dimmer JL, Levin AM, Ray AM, Zuhlke KA, Machiela MJ, Halstead-Nussloch BA, Johnson GR, Cooney KA, Douglas JA
Recent admixture mapping and linkage/association studies have implicated an approximately 1 Mb region on chromosome 8q24 in prostate cancer susceptibility. In a subsequent follow-up investigation, Haiman et al. (Nat Genet 2007;39:638-44) observed significant, independent associations between 7 markers within this region and sporadic prostate cancer risk in a multi-ethnic sample. To clarify the risk associated with hereditary prostate cancer, we tested for prostate cancer association with 6 of these 7 markers in a sample of 1,015 non-Hispanic white men with and without prostate cancer from 403 familial and early-onset prostate cancer families. Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association. Using a family-based association test, the minor ("C") allele of rs6983561 and the major ("G") allele of rs6983267 were preferentially transmitted to affected men (p
___
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer.
To: mesothelioma77@gmail.com
[1]Int J Cancer. 2008 Mar 21;
Beebe-Dimmer JL, Levin AM, Ray AM, Zuhlke KA, Machiela MJ, Halstead-Nussloch BA, Johnson GR, Cooney KA, Douglas JA
Recent admixture mapping and linkage/association studies have implicated an approximately 1 Mb region on chromosome 8q24 in prostate cancer susceptibility. In a subsequent follow-up investigation, Haiman et al. (Nat Genet 2007;39:638-44) observed significant, independent associations between 7 markers within this region and sporadic prostate cancer risk in a multi-ethnic sample. To clarify the risk associated with hereditary prostate cancer, we tested for prostate cancer association with 6 of these 7 markers in a sample of 1,015 non-Hispanic white men with and without prostate cancer from 403 familial and early-onset prostate cancer families. Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association. Using a family-based association test, the minor ("C") allele of rs6983561 and the major ("G") allele of rs6983267 were preferentially transmitted to affected men (p
___
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Fwd: Celgene Corp. Review in Progress
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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Celgene Corp. Review in Progress
To: mesothelioma77@gmail.com
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Celgene Corp. Review in Progress
To: mesothelioma77@gmail.com
MaybachFinancial.com is one of the fastest growing independent and unbiased research firms in the world.
Source: http://www.m2.com/m2/web/story.php/2008A22805C1E877ADC58025741700545813
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Tue, 25 Mar 2008 15:54:03 GMT
Source: http://www.m2.com/m2/web/story.php/2008A22805C1E877ADC58025741700545813
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Fwd: Survivor treasures premiership glory
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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Survivor treasures premiership glory
To: mesothelioma77@gmail.com
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Survivor treasures premiership glory
To: mesothelioma77@gmail.com
Catani Cricket Club treasurer and cancer survivor Bev Hobson is presented with the WGCA A-grade premiership trophy by Blues captain-coach Nic Close on Sunday.
Source: http://www.senews.com.au/story/56481
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Tue, 25 Mar 2008 15:28:05 GMT
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