Skin Cancer Charts Graphs: Fwd: Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Tue, Mar 25, 2008 at 2:49 PM
Subject: Chromosome 8q24 markers: Risk of early-onset and familial prostate cancer.
To: mesothelioma77@gmail.com

[1]Int J Cancer. 2008 Mar 21;
Beebe-Dimmer JL, Levin AM, Ray AM, Zuhlke KA, Machiela MJ, Halstead-Nussloch BA, Johnson GR, Cooney KA, Douglas JA

Recent admixture mapping and linkage/association studies have implicated an approximately 1 Mb region on chromosome 8q24 in prostate cancer susceptibility. In a subsequent follow-up investigation, Haiman et al. (Nat Genet 2007;39:638-44) observed significant, independent associations between 7 markers within this region and sporadic prostate cancer risk in a multi-ethnic sample. To clarify the risk associated with hereditary prostate cancer, we tested for prostate cancer association with 6 of these 7 markers in a sample of 1,015 non-Hispanic white men with and without prostate cancer from 403 familial and early-onset prostate cancer families. Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association. Using a family-based association test, the minor ("C") allele of rs6983561 and the major ("G") allele of rs6983267 were preferentially transmitted to affected men (p

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Source: http://www.hubmed.org/display.cgi?uids=18360876
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