From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 29, 2008 at 3:46 PM
Subject: PIK3CA activating mutations and chemotherapy sensitivity in stage II-III breast cancer.
To: mesothelioma77@gmail.com
[1]Breast Cancer Res. 2008 Mar 27; 10(2): R27
Liedtke C, Cardone L, Tordai A, Yan K, Gomez HL, Barajas Figureoa LJ, Hubbard RE, Valero V, Souchon EA, Symmans WF, Hortobagyi GN, Bardelli A, Pusztai L
ABSTRACT: INTRODUCTION: In vitro evidence suggests that PIK3CA activation may be associated with altered chemotherapy sensitivity in cancer. METHODS: Tumor DNA from 140 patients with stage II-III breast cancer undergoing neoadjuvant chemotherapy was sequenced for PIK3CA mutations on exons 1, 9 and 20. Mutation status was correlated with clinical/pathological parameters and chemotherapy response as (i) pathological complete response [pCR] vs residual cancer or (ii) quantitative residual cancer burden (RCB) scores, including stratification for estrogen receptor (ER) expression status, type of chemotherapy and separate exons individually. RESULTS: 23 patients (16.4%) harbored a PIK3CA mutation, with 12, 11 and no mutation(s) located in exon 9, 20 and 1, respectively. PIK3CA exon 9 mutations were more frequent among node-negative (52% vs 25% p=0.012) compared to node-positive cancers, particularly among ER-positive tumors. pCR rates and RCB scores were similar among patients with wild type and mutant PIK3CA gene, even after stratification by ER-status, chemotherapy regimen (anthracycline- versus anthracycline plus paclitaxel) or exon. CONCLUSION: PIK3CA mutations are not associated with altered sensitivity to preoperative anthracycline- or taxane-based chemotherapies in ER-positive and ER-negative breast cancers. In this study, PIK3CA mutation was associated with a decreased rate of node-positive disease particularly among ER-positive cancers.
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Source: http://www.hubmed.org/display.cgi?uids=18371219
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