From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Wed, Mar 26, 2008 at 2:45 PM
Subject: CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.
To: mesothelioma77@gmail.com
[1]Br J Cancer. 2008 Mar 25;
Pittman AM, Broderick P, Sullivan K, Fielding S, Webb E, Penegar S, Tomlinson I, Houlston RS
Polymorphisms in CASP8 at 2q33.1 have been associated with the risk of developing cancer, specifically, the D302H variant (rs1045485) with breast cancer in the European population and the -652 6N ins/del promoter variant (rs3834129) with multiple tumours including colorectal cancer (CRC) in the Chinese population. We evaluated the relationship between -652 6N ins/del and D302H variants and risk of developing CRC in the UK population by genotyping 4016 cases and 3749 controls. Both variants showed no evidence of an association with risk of developing CRC (P=0.42 and 0.22, respectively). In contrast, the recently identified CRC susceptibility allele rs6983267 mapping to 8q24 was significantly associated with disease risk (P=8.94 x 10(-8)). It is thus very unlikely that variation in CASP8 defined by -652 6N ins/del or D302H influences the risk of CRC in European populations. The implications of our findings both in terms of population-specific effects and publication bias are discussed.British Journal of Cancer advance online publication, 25 March 2008; doi:10.1038/sj.bjc.6604314 www.bjcancer.com.
___
Source: http://www.hubmed.org/display.cgi?uids=18362937
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Financial Wealth Sites:
Wellness With Wealth.Your Financial Wellness Info
Private Student Loans: A Parent's Best Choice?
Consolidate Debt Loans: To Eliminate Credit Card Debts
Consolidate Debt Loans For Your School Debts
School Consolidation Loan Guide
School Loan Consolidation: Your Much Needed Information
Consolidate Debt Loans: For Better Debt Management
Mortgage Loans. Mortgage Loan Refinancing In Britain
Mortgage Refinancing: The Info You Need Before You Refinance
Mortgage Loan Refinancing In Britain
Mortgage Foreclosure Appraisal
Real Estate: Important Things to Remember
Regulations Preventing Foreclosure
Insurance Premiums and Your DUI, DWI
The Role of Insurance Insurance Defined
http://www.lingwellness.com/privatestudentloans.php
http://www.lingwellness.com/mortgagerefinancing.php
http://www.lingwellness.com/privatestudentloans.php
Health Wellness Sites;
Relieve Stress Anxiety Tensions