From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Apr 23, 2008 at 9:04 AM
Subject: Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.
To: mesothelioma77@gmail.com
[1]Int J Cancer. 2008 Apr 18;
Stresemann C, Lyko F
The cytosine analogues 5-azacytosine (azacytidine) and 2'-deoxy-5-azacytidine (decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These compounds function as DNA methyltransferase inhibitors and have shown substantial potency in reactivating epigenetically silenced tumor suppressor genes in vitro. However, it has been difficult to define the mode of action of these drugs in patients and it appears that clinical responses are influenced both by epigenetic alterations and by apoptosis induction. To maximize the clinical efficacy of azacytidine and decitabine it will be important to understand the molecular changes induced by these drugs. In this review, we examine the pharmacological properties of azanucleosides and their interactions with various cellular pathways. Because azacytidine and decitabine are prodrugs, an understanding of the cellular mechanisms mediating transmembrane transport and metabolic activation will be critically important for optimizing patient responses. We also discuss the mechanism of DNA methyltransferase inhibition and emphasize the need for the identification of predictive biomarkers for the further advancement of epigenetic therapies. (c) 2008 Wiley-Liss, Inc.
___
Source: http://www.hubmed.org/display.cgi?uids=18425818
--
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Your Finance:
Debts, Loans And Consolidation Guide And Info:
Consolidate Debt Loans: For Better Debt Management
Consolidate Debt Loans: To Eliminate Credit Card Debts
Consolidate Debt Loans For Your School Debts
Debt Consolidation UK; Secured and Unsecured Debt Consolidation Explained
Private Student Loans: A Parent's Best Choice?
School Consolidation Loan Guide
School Loan Consolidation: Your Much Needed Information
Your Mortgage Guide And Info
How Much Mortgage Can I Afford?
Best Mortgage Rates Refinancing
Connecticut Mortgage Refinancing
Mortgage Loan Refinancing In Britain
UK Mortgage Payment Calculator
Arkansas Refinance Mortgage Rates
Home Loan Rates Berkeley Springs
Mortgage Foreclosure Appraisal
Regulations Preventing Foreclosure
Your Real Estate Guide And Info:
Real Estate: Important Things to Remember
It's All About Your Insurance
Insurance Premiums and Your DUI, DWI
Your DWI And DUI Guide And Info:
Your Pet Dogs Needs
Air Filled Dog Bed: Your Best Friends Comfort
Pet Dogs: Breeds With Behavioral Problems?
Your Health Info
Relieve Stress Anxiety Tensions
Mesothelioma diagnosis: What You Need To Know
More Articles For You