---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, May 22, 2008 at 5:14 PM
Subject: Breast stromal enhancement on MRI is associated with response to neoadjuvant chemotherapy.
To: mesothelioma77@gmail.com
[1]AJR Am J Roentgenol. 2008 Jun; 190(6): 1630-6
Hattangadi J, Park C, Rembert J, Klifa C, Hwang J, Gibbs J, Hylton N
OBJECTIVE: Cancerous neovascular changes in histologically normal-appearing breast tissue have been shown to increase risk for local recurrence after breast-conserving therapy. However, the imaging characteristics of this tissue have not been well studied. We hypothesized that signal enhancement ratios from dynamic contrast-enhanced breast MRI could be used to analyze the contrast kinetics of microvasculature in breast stroma beyond the tumor margin and that this information can be developed to improve local treatment options. MATERIALS AND METHODS: Signal enhancement ratio analysis of nontumor breast stroma was performed on dynamic contrast-enhanced MRI scans of 42 patients who received neoadjuvant chemotherapy for invasive breast cancer performed before chemotherapy (scan 1) and after one cycle of chemotherapy (scan 2). Stromal signal enhancement ratio values were then correlated to several clinical parameters and to clinical outcome using univariate and multivariate analyses. Median follow-up for the group was 52.1 months. RESULTS: On univariate analysis, factors that were significantly associated (p
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Source: http://www.hubmed.org/display.cgi?uids=18492917
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, May 22, 2008 at 5:14 PM
Subject: Breast stromal enhancement on MRI is associated with response to neoadjuvant chemotherapy.
To: mesothelioma77@gmail.com
[1]AJR Am J Roentgenol. 2008 Jun; 190(6): 1630-6
Hattangadi J, Park C, Rembert J, Klifa C, Hwang J, Gibbs J, Hylton N
OBJECTIVE: Cancerous neovascular changes in histologically normal-appearing breast tissue have been shown to increase risk for local recurrence after breast-conserving therapy. However, the imaging characteristics of this tissue have not been well studied. We hypothesized that signal enhancement ratios from dynamic contrast-enhanced breast MRI could be used to analyze the contrast kinetics of microvasculature in breast stroma beyond the tumor margin and that this information can be developed to improve local treatment options. MATERIALS AND METHODS: Signal enhancement ratio analysis of nontumor breast stroma was performed on dynamic contrast-enhanced MRI scans of 42 patients who received neoadjuvant chemotherapy for invasive breast cancer performed before chemotherapy (scan 1) and after one cycle of chemotherapy (scan 2). Stromal signal enhancement ratio values were then correlated to several clinical parameters and to clinical outcome using univariate and multivariate analyses. Median follow-up for the group was 52.1 months. RESULTS: On univariate analysis, factors that were significantly associated (p
___
Source: http://www.hubmed.org/display.cgi?uids=18492917
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