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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Identification of Galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain.
To: mesothelioma77@gmail.com
[1]Cancer Invest. 2008 Jul; 26(6): 615-23
Mayoral MA, Mayoral C, Meneses A, Villalvazo L, Guzman A, Espinosa B, Ochoa JL, Zenteno E, Guevara J
Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fualpha 1,2 (GalNAcalpha 1,3) Galss1,4 in complex mucin) but not for Amaranthus leucocarpus (Galss1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Galss1,3GalNAc/Galss1,4GlcNAc). Mucin-type glycans and Galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and Galectin-3 favor breast cancer progression and brain metastasis.
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Source: http://www.hubmed.org/display.cgi?uids=18584353
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jun 28, 2008 at 4:00 PM
Subject: Identification of Galectin-3 and mucin-type O-glycans in breast cancer and its metastasis to brain.
To: mesothelioma77@gmail.com
[1]Cancer Invest. 2008 Jul; 26(6): 615-23
Mayoral MA, Mayoral C, Meneses A, Villalvazo L, Guzman A, Espinosa B, Ochoa JL, Zenteno E, Guevara J
Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fualpha 1,2 (GalNAcalpha 1,3) Galss1,4 in complex mucin) but not for Amaranthus leucocarpus (Galss1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Galss1,3GalNAc/Galss1,4GlcNAc). Mucin-type glycans and Galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and Galectin-3 favor breast cancer progression and brain metastasis.
___
Source: http://www.hubmed.org/display.cgi?uids=18584353
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Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc