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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jul 19, 2008 at 9:37 PM
Subject: Expression of Indian Hedgehog signaling molecules in breast cancer.
To: mesothelioma77@gmail.com
[1]J Cancer Res Clin Oncol. 2008 Jul 18;
Xuan Y, Lin Z
PURPOSE: To investigate the clinicopathological significance and expression pattern of Hedgehog (Hh) signaling molecules in breast normal glands and invasive ductal carcinoma. MATERIALS AND METHODS: A total of 142 cases, including 21 of normal breast and 121 of invasive ductal carcinoma of the breast, were immunohistochemically analyzed for Ihh, Ptch, Smo, Gli-1, Gli-2, and Gli-3 protein expression. RESULTS: All of Hh signaling molecules were greatly enhanced in invasive ductal carcinoma compared with the normal breast epithelia. The expressions of Ihh, Smo, and Gli-2 were increased in PR negative cases, and the expressions of Ihh, Ptch, and Gli-1/2/3 were statistically correlated with increased proliferating index of Ki-67 in invasive ductal carcinoma. Ihh and Gli-1/2/3 expressions were correlated with node metastasis. Additionally, the protein expressions of Ihh, Ptch, and Gli-2 were correlated with the clinical stage of breast cancer. CONCLUSIONS: Hedgehog signaling molecules play an important role in the progression of invasive ductal carcinoma of breast.
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Source: http://www.hubmed.org/display.cgi?uids=18636275
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jul 19, 2008 at 9:37 PM
Subject: Expression of Indian Hedgehog signaling molecules in breast cancer.
To: mesothelioma77@gmail.com
[1]J Cancer Res Clin Oncol. 2008 Jul 18;
Xuan Y, Lin Z
PURPOSE: To investigate the clinicopathological significance and expression pattern of Hedgehog (Hh) signaling molecules in breast normal glands and invasive ductal carcinoma. MATERIALS AND METHODS: A total of 142 cases, including 21 of normal breast and 121 of invasive ductal carcinoma of the breast, were immunohistochemically analyzed for Ihh, Ptch, Smo, Gli-1, Gli-2, and Gli-3 protein expression. RESULTS: All of Hh signaling molecules were greatly enhanced in invasive ductal carcinoma compared with the normal breast epithelia. The expressions of Ihh, Smo, and Gli-2 were increased in PR negative cases, and the expressions of Ihh, Ptch, and Gli-1/2/3 were statistically correlated with increased proliferating index of Ki-67 in invasive ductal carcinoma. Ihh and Gli-1/2/3 expressions were correlated with node metastasis. Additionally, the protein expressions of Ihh, Ptch, and Gli-2 were correlated with the clinical stage of breast cancer. CONCLUSIONS: Hedgehog signaling molecules play an important role in the progression of invasive ductal carcinoma of breast.
___
Source: http://www.hubmed.org/display.cgi?uids=18636275
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Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc