---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jul 19, 2008 at 9:37 PM
Subject: Terpenoids from the tuber of Cremastra appendiculata.
To: mesothelioma77@gmail.com
[1]J Asian Nat Prod Res. 2008 Jul; 10(7): 677-83
Li S, Xue Z, Wang SJ, Yang YC, Shi JG
Two new terpenoids including a cadinane sesquiterpene (1), and an ent-kaurane diterpene diglycoside (2), together with a known triterpene containing 32 carbons (3), have been isolated from the ethanolic extract of Cremastra appendiculata. Their structures were established by the spectroscopic methods including the IR, MS, 1D-, and 2D-NMR experiments as ( - )-cadin-4,10(15)-dien-11-oic acid (1), ( - )-ent-12beta-hydroxykaur-16-en-19-oic acid, 19-O-beta-d-xylopyranosyl-(1 --> 6)-O-beta-d-glucopyranoside (2), and (+)-24,24-dimethyl-25,32-cyclo-5alpha-lanosta-9(11)-en-3beta-ol (3). Compounds 1-3 were evaluated against several human cancer cell lines. Compound 3 showed in vitro-selective cytotoxicity against human breast cancer cell lines (MCF-7) with an IC(50) of 3.18 muM, but 1 and 2 were inactive (IC(50)>10 mug/ml).
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Source: http://www.hubmed.org/display.cgi?uids=18636382
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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Jul 19, 2008 at 9:37 PM
Subject: Terpenoids from the tuber of Cremastra appendiculata.
To: mesothelioma77@gmail.com
[1]J Asian Nat Prod Res. 2008 Jul; 10(7): 677-83
Li S, Xue Z, Wang SJ, Yang YC, Shi JG
Two new terpenoids including a cadinane sesquiterpene (1), and an ent-kaurane diterpene diglycoside (2), together with a known triterpene containing 32 carbons (3), have been isolated from the ethanolic extract of Cremastra appendiculata. Their structures were established by the spectroscopic methods including the IR, MS, 1D-, and 2D-NMR experiments as ( - )-cadin-4,10(15)-dien-11-oic acid (1), ( - )-ent-12beta-hydroxykaur-16-en-19-oic acid, 19-O-beta-d-xylopyranosyl-(1 --> 6)-O-beta-d-glucopyranoside (2), and (+)-24,24-dimethyl-25,32-cyclo-5alpha-lanosta-9(11)-en-3beta-ol (3). Compounds 1-3 were evaluated against several human cancer cell lines. Compound 3 showed in vitro-selective cytotoxicity against human breast cancer cell lines (MCF-7) with an IC(50) of 3.18 muM, but 1 and 2 were inactive (IC(50)>10 mug/ml).
___
Source: http://www.hubmed.org/display.cgi?uids=18636382
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Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc