Skin Cancer Charts Graphs: Fwd: Clofarabine combinations as acute myeloid leukemia salvage therapy.

Monday, September 15, 2008

Fwd: Clofarabine combinations as acute myeloid leukemia salvage therapy.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Aug 31, 2008 at 7:09 AM
Subject: Clofarabine combinations as acute myeloid leukemia salvage therapy.
To: mesothelioma77@gmail.com

[1]Cancer. 2008 Aug 28;
Faderl S, Ferrajoli A, Wierda W, Huang X, Verstovsek S, Ravandi F, Estrov Z, Borthakur G, Kwari M, Kantarjian HM

BACKGROUND.: Outcome of patients with relapsed acute myeloid leukemia (AML) remains unsatisfactory. Clofarabine is a nucleoside analog with activity in adult AML. Combinations with cytarabine in AML are feasible and effective. Idarubicin is another active AML drug, which has not yet been tested with clofarabine. METHODS.: The authors therefore designed a phase I study of clofarabine +/- cytarabine, plus idarubicin. Patients with primary refractory or first-relapse AML were assigned to either clofarabine plus idarubicin (CI) if previously exposed to cytarabine with a response lasting /=12 months, or if never exposed to cytarabine. A standard "3 + 3" phase 1 design was followed to define maximum tolerated dose (MTD). Forty-four patients were treated (23 CI; 21 CIA). RESULTS.: Dose-limiting toxicities were hyperbilirubinemia and hepatic transaminase elevations for CI-treated patients in addition to mucositis and diarrhea for CIA-treated patients. MTD for CI was clofarabine 22.5 mg/m(2) intravenously daily x 5 and idarubicin 10 mg/m(2) intravenously daily x 3. MTD for CIA was clofarabine 22.5 mg/m(2) intravenously x 5, idarubicin 6 mg/m(2) intravenously x 3, and cytarabine 0.75 g/m(2) intravenously x 5 days. CONCLUSIONS.: A phase 2 randomized trial is in process to compare activity between treatment arms. Cancer 2008. (c) 2008 American Cancer Society.

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Source: http://www.hubmed.org/display.cgi?uids=18756533
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