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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 7, 2008 at 3:45 AM
Subject: Effects of Iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines.
To: mesothelioma77@gmail.com
[1]J Cell Biochem. 2008 Sep 4;
Wang WL, McHenry P, Jeffrey R, Schweitzer D, Helquist P, Tenniswood M
Iejimalide B, a marine macrolide, causes growth inhibition in a variety of cancer cell lines at nanomolar concentrations. We have investigated the effects of Iejimalide B on cell cycle kinetics and apoptosis in the p53(+)/AR(+) LNCaP and p53(-)/AR(-) PC-3 prostate cancer cell lines. Iejimalide B, has a dose and time dependent effect on cell number (as measured by crystal violet assay) in both cell lines. In LNCaP cells Iejimalide B induces a dose dependent G(0)/G(1) arrest and apoptosis at 48 h (as measured by Apo-BrdU staining). In contrast, Iejimalide B initially induces G(0)/G(1) arrest followed by S phase arrest but does not induce apoptosis in PC-3 cells. qPCR and Western analysis suggests that Iejimalide B modulates the steady state level of many gene products associated with cell cycle (including cyclins D, E, and B and p21(waf1/cip1)) and cell death (including survivin, p21B and BNIP3L) in LNCaP cells. In PC-3 cells Iejimalide B induces the expression of p21(waf1/cip1), down regulates the expression of cyclin A, and does not modulate the expression of the genes associated with cell death. Comparison of the effects of Iejimalide B on the two cell lines suggests that Iejimalide B induces cell cycle arrest by two different mechanisms and that the induction of apoptosis in LNCaP cells is p53-dependent. J. Cell. Biochem. (c) 2008 Wiley-Liss, Inc.
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Source: http://www.hubmed.org/display.cgi?uids=18773415
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 7, 2008 at 3:45 AM
Subject: Effects of Iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines.
To: mesothelioma77@gmail.com
[1]J Cell Biochem. 2008 Sep 4;
Wang WL, McHenry P, Jeffrey R, Schweitzer D, Helquist P, Tenniswood M
Iejimalide B, a marine macrolide, causes growth inhibition in a variety of cancer cell lines at nanomolar concentrations. We have investigated the effects of Iejimalide B on cell cycle kinetics and apoptosis in the p53(+)/AR(+) LNCaP and p53(-)/AR(-) PC-3 prostate cancer cell lines. Iejimalide B, has a dose and time dependent effect on cell number (as measured by crystal violet assay) in both cell lines. In LNCaP cells Iejimalide B induces a dose dependent G(0)/G(1) arrest and apoptosis at 48 h (as measured by Apo-BrdU staining). In contrast, Iejimalide B initially induces G(0)/G(1) arrest followed by S phase arrest but does not induce apoptosis in PC-3 cells. qPCR and Western analysis suggests that Iejimalide B modulates the steady state level of many gene products associated with cell cycle (including cyclins D, E, and B and p21(waf1/cip1)) and cell death (including survivin, p21B and BNIP3L) in LNCaP cells. In PC-3 cells Iejimalide B induces the expression of p21(waf1/cip1), down regulates the expression of cyclin A, and does not modulate the expression of the genes associated with cell death. Comparison of the effects of Iejimalide B on the two cell lines suggests that Iejimalide B induces cell cycle arrest by two different mechanisms and that the induction of apoptosis in LNCaP cells is p53-dependent. J. Cell. Biochem. (c) 2008 Wiley-Liss, Inc.
___
Source: http://www.hubmed.org/display.cgi?uids=18773415
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