From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 28, 2008 at 4:45 AM
Subject: Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis.
To: mesothelioma77@gmail.com
[1]Cell Stress Chaperones. 2008 Sep 26;
Chow AM, Steel R, Anderson RL
In addition to its role as a molecular chaperone, heat shock protein 72 (Hsp72) protects cells against a wide range of apoptosis inducing stresses. However, it is unclear if these two roles are functionally related or whether Hsp72 inhibits apoptosis by a mechanism independent of chaperone activity. The N-terminal adenosine triphosphatase domain, substrate-binding domain and the C-terminal EEVD regulatory motif of Hsp72 are all essential for chaperone activity. In this study, we show that Hsp72 mutants with a functional substrate-binding domain but lacking chaperone activity retain their ability to protect cells against apoptosis induced by heat and tumor necrosis factor alpha. In contrast, a deletion mutant lacking a functional substrate-binding domain has no protective capacity. The ability of the Hsp72 substrate-binding domain to inhibit apoptosis independent of the regulatory effects of the adenosine triphosphate-binding domain indicates that the inhibition of apoptosis may involve a stable binding interaction with a regulatory substrate rather than Hsp72 chaperone activity.
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Source: http://www.hubmed.org/display.cgi?uids=18819021
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