From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sun, May 11, 2008 at 6:20 PM
Subject: Decision making regarding prophylactic mastectomy: stability of preferences and the impact of anticipated feelings of regret.
To: mesothelioma77@gmail.com
[1]J Clin Oncol. 2008 May 10; 26(14): 2358-63
van Dijk S, van Roosmalen MS, Otten W, Stalmeier PF
PURPOSE: Women who test positive for a BRCA1/2 mutation face difficult choices to manage their breast cancer risk; one of these choices is whether to opt for prophylactic mastectomy. Few data are available about this decision-making process. The current study provides data regarding the stability of risk-management preferences over time and the factors that are associated with these preferences. PATIENTS AND METHODS: We analyzed data from 338 women who opted for breast cancer antigen (BRCA) testing. First, we prospectively assessed preferences of 80 BRCA mutation carriers at five different points in time ranging from 1 week after blood sampling up to 9 months after BRCA-test disclosure. Second, we applied univariate and multivariate regression analyses to examine which medical, sociodemographic, and psychological factors are related to a preference for prophylactic mastectomy. RESULTS: Ninety percent of the women already indicated a preference regarding risk management at baseline. Moreover, most women had stable preferences over time. Furthermore, anticipated feelings of regret in case of a hypothetical breast cancer diagnosis in the near future were strongly related to risk-management preference (odds ratio = 8.93; P
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Source: http://www.hubmed.org/display.cgi?uids=18467728
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