Skin Cancer Charts Graphs: Fwd: Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 7, 2008 at 3:45 AM
Subject: Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.
To: mesothelioma77@gmail.com

[1]Dev Dyn. 2008 Sep 4;
Lou Y, Preobrazhenska O, Auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S

Epithelial-mesenchymal transition (EMT) has been linked to metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability. Contrary to expectations, 67NR cells, which form primary tumors but fail to metastasize, express vimentin and N-cadherin, but not E-cadherin. 4T1 cells express E-cadherin and ZO-1, but are migratory, invasive, and metastasize to multiple sites. 66cl4 cells form lung metastases and display a mixed phenotype, but are not as migratory or invasive as 67NR cells. These findings demonstrate that the metastatic ability of breast cancer cells does not strictly correlate with genotypic and phenotypic properties of EMT per se, and suggest that other processes may govern metastatic capability. Gene expression analysis of primary tumors did not identify differences in EMT markers, but did reveal candidate genes that may influence metastatic ability. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc.

___
Source: http://www.hubmed.org/display.cgi?uids=18773493
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc

Freshen Your Day. Watch and Upload Some Of Your Humor And Funny Stuffs, Funny Videos

More Links and Info Sites For Your Searches

Search Info Source

Humor and Funny Stuffs

Funny Tagalog Quotes, Funny Short Skits, Funny Car Commercials

I Need Some Funny Jokes Riddles For Teenagers, Really Funny Quick Jokes

Funny Goodbye Letters, Funny Rude Free Ecards, Funny Sick Twisted Humor

Funny Videos and Entertainment

Funny Videos

What Is The Average Price of Life Insurance

How Much Does Life Insurance Cost